Intra-adipose sex steroid metabolism and body fat distribution in idiopathic human obesity

Deborah J Wake, Magnus Strand, Eva Rask, Jukka Westerbacka, Dawn E W Livingstone, Stefan Soderberg, Ruth Andrew, Hannele Yki-Jarvinen, Tommy Olsson, Brian R Walker

Research output: Contribution to journalArticlepeer-review

Abstract

Causes of visceral fat accumulation include glucocorticoid excess or decreased oestrogen/androgen ratio either in plasma or within adipose tissue. In obese subjects, the intra-adipose cortisol-generating enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is increased, but information on sex steroid signalling is sparse. We aimed to test associations between body fat or fat distribution and mRNA transcript levels for androgen and oestrogen receptors and for enzymes metabolizing sex steroids in adipose tissue.
Original languageEnglish
Pages (from-to)440-6
Number of pages7
JournalClinical Endocrinology
Volume66
Issue number3
DOIs
Publication statusPublished - 2007

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