Intracerebral hematomas disappear on T2*-weighted images during normobaric oxygen therapy

Thomas Gaberel, Clement Gakuba, Marie Hebert, Axel Montagne, Veronique Agin, Marina Rubio, Evelyne Emery, Denis Vivien, Maxime Gauberti

Research output: Contribution to journalArticlepeer-review


BACKGROUND AND PURPOSE: The aim of the present study was to investigate the effects of normobaric oxygen (NBO) therapy on T2*-weighted images of intracranial hemorrhages (ICHs).

METHODS: Two common models of ICH were performed in mice, and longitudinal T2*-weighted images of the hematomas were acquired under normoxia or NBO. The effects of NBO were also investigated on perfusion-weighted imaging, susceptibility-weighted imaging, and molecular imaging of vascular cell adhesion molecule-1 after ICH. Last, we performed neurological testing, including neuroscore, actimetry, and gait analysis (Catwalk), to study the influence of NBO on neurological outcome of mice presenting ICH.

RESULTS: Our results demonstrated that NBO, even during a short period of time, dramatically reduces the sensitivity of T2*-weighted imaging to detect ICH. Moreover, we provide evidence that the disappearance of ICH on T2*-weighted imaging could be used to improve accuracy of perfusion-weighted imaging and to allow molecular imaging after ICH. Importantly, a 30-minute NBO preparation 24 hours after ICH onset does not influence neurological outcome.

CONCLUSIONS: We provide an experimental demonstration that NBO significantly affects T2*-weighted imaging in ICH. Although this phenomenon could lead to inaccurate assessment of ICH volume, it could also be safely used to allow perfusion-weighted imaging and molecular imaging.

Original languageEnglish
Pages (from-to)3482-9
Number of pages8
Issue number12
Publication statusPublished - Dec 2013


  • Animals
  • Brain/pathology
  • Intracranial Hemorrhages/blood
  • Magnetic Resonance Imaging
  • Mice
  • Oxygen/blood
  • Oxygen Inhalation Therapy
  • Treatment Outcome


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