Intracerebral hemorrhage location and outcome among INTERACT2 participants

Candice Delcourt; Shoichiro Sato; Shihong Zhang; Else Charlotte Sandset; Danni Zheng; xiaoying Chen; Maree L Hackett; Hisatomi Arima; Jun Hata; Emma Heeley; Rustam Salman; Thompson Robinson; Leo Davies; Pablo M Lavados; Richard  Lindley; Christian Stapf; John Chalmers; Craig S Anderson

doi:10.​1212/​WNL.​0000000000003771

Intracerebral hemorrhage location and outcome among INTERACT2 participants

Candice Delcourt, Shoichiro Sato, Shihong Zhang, Else Charlotte Sandset, Danni Zheng, xiaoying Chen, Maree L Hackett, Hisatomi Arima, Jun Hata, Emma Heeley, Rustam Salman, Thompson Robinson, Leo Davies, Pablo M Lavados, Richard Lindley, Christian Stapf, John Chalmers, Craig S Anderson

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: We aimed to clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase, Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2).
Methods: Associations between ICH sites and poor outcomes (death [6] and/or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90-day were assessed in logistic regression models.
Results: Of 2066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (≤0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all HRQoL domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively).
Conclusions: Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule.

Original language	English
Journal	Neurology
Early online date	24 Feb 2017
DOIs	https://doi.org/10.1212/WNL.0000000000003771
Publication status	E-pub ahead of print - 24 Feb 2017

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10.1212/WNL.0000000000003771

Intracerebral hemorrhage location and outcome among INTERACT2 participants
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http://www.neurology.org/content/early/2017/02/24/WNL.0000000000003771.short

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Delcourt, C., Sato, S., Zhang, S., Sandset, E. C., Zheng, D., Chen, X., Hackett, M. L., Arima, H., Hata, J., Heeley, E., Salman, R., Robinson, T., Davies, L., Lavados, P. M., Lindley, R., Stapf, C., Chalmers, J., & Anderson, C. S. (2017). Intracerebral hemorrhage location and outcome among INTERACT2 participants. Neurology. https://doi.org/10.1212/WNL.0000000000003771

@article{c6c2f00fd91a429bbe2f9ec8e52da9f8,

title = "Intracerebral hemorrhage location and outcome among INTERACT2 participants",

abstract = "Objective: We aimed to clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase, Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2).Methods: Associations between ICH sites and poor outcomes (death [6] and/or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90-day were assessed in logistic regression models. Results: Of 2066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (≤0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all HRQoL domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively). Conclusions: Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule.",

author = "Candice Delcourt and Shoichiro Sato and Shihong Zhang and Sandset, {Else Charlotte} and Danni Zheng and xiaoying Chen and Hackett, {Maree L} and Hisatomi Arima and Jun Hata and Emma Heeley and Rustam Salman and Thompson Robinson and Leo Davies and Lavados, {Pablo M} and Richard Lindley and Christian Stapf and John Chalmers and Anderson, {Craig S}",

year = "2017",

month = feb,

day = "24",

doi = "10.1212/WNL.0000000000003771",

language = "English",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - Intracerebral hemorrhage location and outcome among INTERACT2 participants

AU - Delcourt, Candice

AU - Sato, Shoichiro

AU - Zhang, Shihong

AU - Sandset, Else Charlotte

AU - Zheng, Danni

AU - Chen, xiaoying

AU - Hackett, Maree L

AU - Arima, Hisatomi

AU - Hata, Jun

AU - Heeley, Emma

AU - Salman, Rustam

AU - Robinson, Thompson

AU - Davies, Leo

AU - Lavados, Pablo M

AU - Lindley, Richard

AU - Stapf, Christian

AU - Chalmers, John

AU - Anderson, Craig S

PY - 2017/2/24

Y1 - 2017/2/24

N2 - Objective: We aimed to clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase, Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2).Methods: Associations between ICH sites and poor outcomes (death [6] and/or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90-day were assessed in logistic regression models. Results: Of 2066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (≤0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all HRQoL domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively). Conclusions: Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule.

AB - Objective: We aimed to clarify associations between intracerebral hemorrhage (ICH) location and clinical outcomes among participants of the main phase, Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2).Methods: Associations between ICH sites and poor outcomes (death [6] and/or major disability [3-5] of modified Rankin Scale) and European Quality of Life Scale (EQ-5D) utility scores at 90-day were assessed in logistic regression models. Results: Of 2066 patients included in the analyses, associations were identified between ICH sites and poor outcomes: involvement of posterior limb of internal capsule increased risks of death or major disability (odds ratio [OR] 2.10) and disability (OR 1.81); thalamic involvement increased risks of death or major disability (OR 2.24) and death (OR 1.97). Involvement of the posterior limb of the internal capsule, thalamus, and infratentorial sites were each associated with poor EQ-5D utility score (≤0.7 [median]; OR 1.87, 2.14, and 2.81, respectively). Posterior limb of internal capsule involvement was strongly associated with low scores across all HRQoL domains. ICH encompassing the thalamus and posterior limb of internal capsule were associated with death or major disability, major disability and poor EQ-5D utility score (OR 1.72, 2.26, and 1.71, respectively). Conclusions: Poor clinical outcomes are related to ICH affecting the posterior limb of internal capsule, thalamus, and infratentorial sites. The highest association with death or major disability and poor EQ-5D utility score was seen in ICH encompassing the thalamus and posterior limb of internal capsule.

U2 - 10.1212/WNL.0000000000003771

DO - 10.1212/WNL.0000000000003771

M3 - Article

JO - Neurology

JF - Neurology

SN - 0028-3878

ER -

Intracerebral hemorrhage location and outcome among INTERACT2 participants

Abstract

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