Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling

Rajesh Katare; Andrea Caporali; Lorena Zentilin; Elisa Avolio; Graciela Sala-Newby; Atsuhiko Oikawa; Daniela Cesselli; Antonio Paolo Beltrami; Mauro Giacca; Costanza Emanueli; Paolo Madeddu

doi:10.1161/CIRCRESAHA.110.239111

Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling

Rajesh Katare, Andrea Caporali, Lorena Zentilin, Elisa Avolio, Graciela Sala-Newby, Atsuhiko Oikawa, Daniela Cesselli, Antonio Paolo Beltrami, Mauro Giacca, Costanza Emanueli, Paolo Madeddu

Research output: Contribution to journal › Article › peer-review

Abstract

Studies in transgenic mice showed the key role of (Pim-1) (proviral integration site for Moloney murine leukemia virus-1) in the control of cardiomyocyte function and viability.

Original language	English
Pages (from-to)	1238-51
Number of pages	14
Journal	Circulation Research
Volume	108
Issue number	10
DOIs	https://doi.org/10.1161/CIRCRESAHA.110.239111
Publication status	Published - 13 May 2011

Keywords

Animals
Apoptosis
Cell Survival
Cells, Cultured
Diabetic Cardiomyopathies
Disease Progression
Genetic Therapy
Genetic Vectors
Glucose
Humans
Injections, Intravenous
Male
Mice
Plasmids
Proto-Oncogene Proteins c-pim-1
Rats
Rats, Wistar
Signal Transduction

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10.1161/CIRCRESAHA.110.239111

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Katare, R., Caporali, A., Zentilin, L., Avolio, E., Sala-Newby, G., Oikawa, A., Cesselli, D., Beltrami, A. P., Giacca, M., Emanueli, C., & Madeddu, P. (2011). Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling. Circulation Research, 108(10), 1238-51. https://doi.org/10.1161/CIRCRESAHA.110.239111

Katare, Rajesh ; Caporali, Andrea ; Zentilin, Lorena ; Avolio, Elisa ; Sala-Newby, Graciela ; Oikawa, Atsuhiko ; Cesselli, Daniela ; Beltrami, Antonio Paolo ; Giacca, Mauro ; Emanueli, Costanza ; Madeddu, Paolo. / Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling. In: Circulation Research. 2011 ; Vol. 108, No. 10. pp. 1238-51.

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title = "Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling",

abstract = "Studies in transgenic mice showed the key role of (Pim-1) (proviral integration site for Moloney murine leukemia virus-1) in the control of cardiomyocyte function and viability.",

keywords = "Animals, Apoptosis, Cell Survival, Cells, Cultured, Diabetic Cardiomyopathies, Disease Progression, Genetic Therapy, Genetic Vectors, Glucose, Humans, Injections, Intravenous, Male, Mice, Plasmids, Proto-Oncogene Proteins c-pim-1, Rats, Rats, Wistar, Signal Transduction",

author = "Rajesh Katare and Andrea Caporali and Lorena Zentilin and Elisa Avolio and Graciela Sala-Newby and Atsuhiko Oikawa and Daniela Cesselli and Beltrami, {Antonio Paolo} and Mauro Giacca and Costanza Emanueli and Paolo Madeddu",

year = "2011",

month = may,

day = "13",

doi = "10.1161/CIRCRESAHA.110.239111",

language = "English",

volume = "108",

pages = "1238--51",

journal = "Circulation Research",

issn = "0009-7330",

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}

Katare, R, Caporali, A, Zentilin, L, Avolio, E, Sala-Newby, G, Oikawa, A, Cesselli, D, Beltrami, AP, Giacca, M, Emanueli, C & Madeddu, P 2011, 'Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling', Circulation Research, vol. 108, no. 10, pp. 1238-51. https://doi.org/10.1161/CIRCRESAHA.110.239111

Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling. / Katare, Rajesh; Caporali, Andrea; Zentilin, Lorena; Avolio, Elisa; Sala-Newby, Graciela; Oikawa, Atsuhiko; Cesselli, Daniela; Beltrami, Antonio Paolo; Giacca, Mauro; Emanueli, Costanza; Madeddu, Paolo.

In: Circulation Research, Vol. 108, No. 10, 13.05.2011, p. 1238-51.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling

AU - Katare, Rajesh

AU - Caporali, Andrea

AU - Zentilin, Lorena

AU - Avolio, Elisa

AU - Sala-Newby, Graciela

AU - Oikawa, Atsuhiko

AU - Cesselli, Daniela

AU - Beltrami, Antonio Paolo

AU - Giacca, Mauro

AU - Emanueli, Costanza

AU - Madeddu, Paolo

PY - 2011/5/13

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N2 - Studies in transgenic mice showed the key role of (Pim-1) (proviral integration site for Moloney murine leukemia virus-1) in the control of cardiomyocyte function and viability.

AB - Studies in transgenic mice showed the key role of (Pim-1) (proviral integration site for Moloney murine leukemia virus-1) in the control of cardiomyocyte function and viability.

KW - Animals

KW - Apoptosis

KW - Cell Survival

KW - Cells, Cultured

KW - Diabetic Cardiomyopathies

KW - Disease Progression

KW - Genetic Therapy

KW - Genetic Vectors

KW - Glucose

KW - Humans

KW - Injections, Intravenous

KW - Male

KW - Mice

KW - Plasmids

KW - Proto-Oncogene Proteins c-pim-1

KW - Rats

KW - Rats, Wistar

KW - Signal Transduction

U2 - 10.1161/CIRCRESAHA.110.239111

DO - 10.1161/CIRCRESAHA.110.239111

M3 - Article

C2 - 21474815

VL - 108

SP - 1238

EP - 1251

JO - Circulation Research

JF - Circulation Research

SN - 0009-7330

IS - 10

ER -

Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling

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Keywords

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