Intravenous gene therapy with PIM-1 via a cardiotropic viral vector halts the progression of diabetic cardiomyopathy through promotion of prosurvival signaling

Rajesh Katare, Andrea Caporali, Lorena Zentilin, Elisa Avolio, Graciela Sala-Newby, Atsuhiko Oikawa, Daniela Cesselli, Antonio Paolo Beltrami, Mauro Giacca, Costanza Emanueli, Paolo Madeddu

Research output: Contribution to journalArticlepeer-review

Abstract

Studies in transgenic mice showed the key role of (Pim-1) (proviral integration site for Moloney murine leukemia virus-1) in the control of cardiomyocyte function and viability.
Original languageEnglish
Pages (from-to)1238-51
Number of pages14
JournalCirculation Research
Volume108
Issue number10
DOIs
Publication statusPublished - 13 May 2011

Keywords

  • Animals
  • Apoptosis
  • Cell Survival
  • Cells, Cultured
  • Diabetic Cardiomyopathies
  • Disease Progression
  • Genetic Therapy
  • Genetic Vectors
  • Glucose
  • Humans
  • Injections, Intravenous
  • Male
  • Mice
  • Plasmids
  • Proto-Oncogene Proteins c-pim-1
  • Rats
  • Rats, Wistar
  • Signal Transduction

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