Intravitreal therapy for neovascular age-related macular degeneration and inter-individual variations in vitreous pharmacokinetics

Augustinus Laude, Lay Ean Tan, Clive G Wilson, Gerassimos Lascaratos, Mohammed Elashry, Tariq Aslam, Niall Patton, Baljean Dhillon

Research output: Contribution to journalArticlepeer-review

Abstract

This article aims to provide an interpretation and perspective on current concepts and recent literature regarding the evidence for individualizing intravitreal therapy (IVT), particularly considering iatrogenic and patient factors in the management of neovascular age-related macular degeneration (AMD). As ocular parameters that govern IVT pharmacokinetics do vary between individuals with AMD, developing a personalized strategy could improve safety and efficacy. This has to be derived from clinical measurements and data from laboratory animals; however, it is recognized that the animal models used in the development of intraocular formulations differ in their vitreous geometry from humans. These factors may be of relevance to the design of ophthalmic formulations and optimizing treatment outcomes in AMD. Further studies are needed to drive improvements in clinical practice which are aimed at maximizing the efficacy profile in IVT for AMD by a more rigorous evaluation of patient and surgeon-related variables.
Original languageEnglish
Pages (from-to)466-75
Number of pages10
JournalProgress in Retinal and Eye Research
Volume29
Issue number6
DOIs
Publication statusPublished - Nov 2010

Keywords

  • Vitreous Body
  • Animals
  • Vitrectomy
  • Humans
  • Macular Degeneration
  • Models, Biological
  • Angiogenesis Inhibitors
  • Intravitreal Injections
  • Individuality
  • Choroidal Neovascularization

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