INTRINSIC CURVATURE: A MARKER OF MILLIMETER-SCALE TANGENTIAL CORTICO-CORTICAL CONNECTIVITY?

Lisa Ronan, Rudolph Pienaar, Guy Williams, Ed Bullmore, Tim J. Crow, Neil Roberts, Peter B. Jones, John Suckling, Paul C. Fletcher

Research output: Contribution to journalArticlepeer-review

Abstract

In this paper, we draw a link between cortical intrinsic curvature and the distributions of tangential connection lengths. We suggest that differential rates of surface expansion not only lead to intrinsic curvature of the cortical sheet, but also to differential inter-neuronal spacing. We propose that there follows a consequential change in the profile of neuronal connections: specifically an enhancement of the tendency towards proportionately more short connections. Thus, the degree of cortical intrinsic curvature may have implications for short-range connectivity.

Original languageEnglish
Pages (from-to)351-366
Number of pages16
JournalInternational Journal of Neural Systems
Volume21
Issue number5
DOIs
Publication statusPublished - Oct 2011

Keywords

  • cortical connectivity
  • WHITE-MATTER
  • SYSTEM
  • VISUAL-CORTEX
  • PREFRONTAL CORTEX
  • SURFACE-BASED ANALYSIS
  • HUMAN CEREBRAL-CORTEX
  • NETWORKS
  • Intrinsic curvature
  • BRAIN SIZE
  • COMMUNICATION
  • SCHIZOPHRENIA
  • surface morphology

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