Intron Size and Exon Evolution in Drosophila

Gabriel Marais, P Nouvellet, Peter Keightley, Brian Charlesworth

Research output: Contribution to journalArticlepeer-review

Abstract

We have found a negative correlation between evolutionary rate at the protein level (as measured by dN) and intron size in Drosophila. Although such a relation is expected if introns reduce Hill-Robertson interference within genes, it seems more likely to be explained by the higher abundance of cis-regulatory elements in introns (especially first introns) in genes under strong selective constraints.
Original languageEnglish
Pages (from-to)481-485
JournalGenetics
Volume170
Issue number1
DOIs
Publication statusPublished - 2005

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