Intron Size and Exon Evolution in Drosophila

Gabriel Marais; P Nouvellet; Peter Keightley; Brian Charlesworth

doi:10.1534/genetics.104.037333

Intron Size and Exon Evolution in Drosophila

Gabriel Marais, P Nouvellet, Peter Keightley, Brian Charlesworth

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

We have found a negative correlation between evolutionary rate at the protein level (as measured by dN) and intron size in Drosophila. Although such a relation is expected if introns reduce Hill-Robertson interference within genes, it seems more likely to be explained by the higher abundance of cis-regulatory elements in introns (especially first introns) in genes under strong selective constraints.

Original language	English
Pages (from-to)	481-485
Journal	Genetics
Volume	170
Issue number	1
DOIs	https://doi.org/10.1534/genetics.104.037333
Publication status	Published - 2005

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10.1534/genetics.104.037333

New methods for understanding the functional significance of noncoding DNA
Keightley, P. (Principal Investigator) & Charlesworth, B. (Co-investigator)
UK-based charities
1/08/03 → 30/11/07
Project: Research

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title = "Intron Size and Exon Evolution in Drosophila",

abstract = "We have found a negative correlation between evolutionary rate at the protein level (as measured by dN) and intron size in Drosophila. Although such a relation is expected if introns reduce Hill-Robertson interference within genes, it seems more likely to be explained by the higher abundance of cis-regulatory elements in introns (especially first introns) in genes under strong selective constraints.",

author = "Gabriel Marais and P Nouvellet and Peter Keightley and Brian Charlesworth",

year = "2005",

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AU - Marais, Gabriel

AU - Nouvellet, P

AU - Keightley, Peter

AU - Charlesworth, Brian

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AB - We have found a negative correlation between evolutionary rate at the protein level (as measured by dN) and intron size in Drosophila. Although such a relation is expected if introns reduce Hill-Robertson interference within genes, it seems more likely to be explained by the higher abundance of cis-regulatory elements in introns (especially first introns) in genes under strong selective constraints.

U2 - 10.1534/genetics.104.037333

DO - 10.1534/genetics.104.037333

M3 - Article

SN - 0016-6731

VL - 170

SP - 481

EP - 485

JO - Genetics

JF - Genetics

IS - 1

ER -

Intron Size and Exon Evolution in Drosophila

Abstract

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New methods for understanding the functional significance of noncoding DNA

Cite this