Projects per year
Abstract / Description of output
The CD4+/CD8+ ratio is used as a marker of the immune regulation of T cell balance. When the ratio in peripheral blood is less than 1, this is considered an indication of immune suppression in an individual. Previous work on bovine Peripheral Blood Mononuclear Cells (PBMC) has consistently reported a ratio ≥1 as seen in other mammalian hosts, i.e. higher circulating CD4+ cell numbers than CD8+ cell numbers. However, a consistent inverted CD4+/CD8+ ratio (<1) was observed in Boran cattle, an African Bos indicus breed. The T cell populations were characterized in Boran cattle (n=52), revealing higher percentages of circulating CD8+ cells (31.9% average) than CD4+ cells (19.1% average), thus resulting in the inversion of the expected T cell homeostasis in these animals. The results show that this inversion is not an effect of age or relatedness of the cattle, rather, it was shared by almost all Boran cattle used in this study. Despite this inversion being a feature shared by both males and females, the female cattle had significantly higher CD4+/CD8+ ratios than the male Boran.
This paper describes the characteristics of the T cell fractions in the study animals and compares the findings to those of other Boran cattle in Kenya, and four other cattle breeds representing African indicine, African taurine, Brazilian indicine and European taurine cattle. We demonstrate that the consistent observation of inverted CD4+/CD8+ cell ratio was restricted to the Boran.
Original language | English |
---|---|
Journal | Veterinary Immunology and Immunopathology |
Early online date | 6 Oct 2020 |
DOIs | |
Publication status | E-pub ahead of print - 6 Oct 2020 |
Keywords / Materials (for Non-textual outputs)
- CD8
- CD4/CD8 ratio
- gamma delta T cells
- Boran cattle
- Peripheral blood mononuclear cells (PBMC)
- Bos indicus
Fingerprint
Dive into the research topics of 'Inverted CD4+/CD8+ T cell ratio in Boran (Bos indicus) cattle'. Together they form a unique fingerprint.Projects
- 1 Finished
-
GCRF-BBR: Beyond the genome: Enabling tropical livestock EWAS of infectious diseases
Prendergast, J. & Morrison, L.
1/07/17 → 30/06/18
Project: Research
Research output
- 1 Article
-
Corrigendum: Inverted CD4 +/CD8+T cell ratio in Boran (Bos indicus) cattle
Makau, M. C., Powell, J., Prendergast, J., de Laté, P. L., Morrison, L. J., Fisch, A., Gathura, P., Kitala, P., Connelley, T. & Toye, P., 18 Mar 2021, (E-pub ahead of print) In: Veterinary Immunology and Immunopathology. 110219.Research output: Contribution to journal › Article › peer-review
Open AccessFile