Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer’s disease

Daniel Mccartney, Anna Stevenson, Rosie Walker, Jude Gibson, Stewart W Morris, Archibald Campbell, Alison D. Murray, Heather Whalley, David Porteous, Andrew McIntosh, Kathryn Evans, Ian Deary, Riccardo Marioni

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Introduction The “epigenetic clock” is a DNA methylation–based estimate of biological age and is correlated with chronological age—the greatest risk factor for Alzheimer's disease (AD). Genetic and environmental risk factors exist for AD, several of which are potentially modifiable. In this study, we assess the relationship between the epigenetic clock and AD risk factors. Methods Multilevel models were used to assess the relationship between age acceleration (the residual of biological age regressed onto chronological age) and AD risk factors relating to cognitive reserve, lifestyle, disease, and genetics in the Generation Scotland study (n = 5100). Results We report significant associations between the epigenetic clock and body mass index, total cholesterol to high-density lipoprotein cholesterol ratios, socioeconomic status, high blood pressure, and smoking behavior (Bonferroni-adjusted P < .05). Discussion Associations are present between environmental risk factors for AD and age acceleration. Measures to modify such risk factors might improve the risk profile for AD and the rate of biological ageing. Future longitudinal analyses are therefore warranted.
Original languageEnglish
JournalAlzheimer's & Dementia: The Journal of the Alzheimer's Association
Early online date21 Jun 2018
Publication statusE-pub ahead of print - 21 Jun 2018


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