Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer’s disease

Daniel Mccartney; Anna Stevenson; Rosie Walker; Jude Gibson; Stewart W Morris; Archibald Campbell; Alison D. Murray; Heather Whalley; David Porteous; Andrew McIntosh; Kathryn Evans; Ian Deary; Riccardo Marioni

doi:10.1016/j.dadm.2018.05.006

Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer’s disease

Daniel Mccartney, Anna Stevenson, Rosie Walker, Jude Gibson, Stewart W Morris, Archibald Campbell, Alison D. Murray, Heather Whalley, David Porteous, Andrew McIntosh, Kathryn Evans, Ian Deary, Riccardo Marioni

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction The “epigenetic clock” is a DNA methylation–based estimate of biological age and is correlated with chronological age—the greatest risk factor for Alzheimer's disease (AD). Genetic and environmental risk factors exist for AD, several of which are potentially modifiable. In this study, we assess the relationship between the epigenetic clock and AD risk factors. Methods Multilevel models were used to assess the relationship between age acceleration (the residual of biological age regressed onto chronological age) and AD risk factors relating to cognitive reserve, lifestyle, disease, and genetics in the Generation Scotland study (n = 5100). Results We report significant associations between the epigenetic clock and body mass index, total cholesterol to high-density lipoprotein cholesterol ratios, socioeconomic status, high blood pressure, and smoking behavior (Bonferroni-adjusted P < .05). Discussion Associations are present between environmental risk factors for AD and age acceleration. Measures to modify such risk factors might improve the risk profile for AD and the rate of biological ageing. Future longitudinal analyses are therefore warranted.

Original language	English
Journal	Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Early online date	21 Jun 2018
DOIs	https://doi.org/10.1016/j.dadm.2018.05.006
Publication status	E-pub ahead of print - 21 Jun 2018

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10.1016/j.dadm.2018.05.006

2018-06-21 Alz & Dem DNAm Uncorrected ProofProof, 642 KBLicence: CC BY

Omics prediction of Alzheimer's disease
Marioni, R. (Principal Investigator)
UK-based charities
1/10/17 → 31/01/21
Project: Research
Stratifying Resilience and Depression Longitudinally
McIntosh, A. (Principal Investigator), Deary, I. (Co-investigator), Evans, K. (Co-investigator), Haley, C. (Co-investigator) & Porteous, D. (Co-investigator)
UK-based charities
1/01/15 → 30/06/21
Project: Research
MRC Dementias Platform
Deary, I. (Principal Investigator)
Other
1/04/14 → 31/03/20
Project: Research

Cite this

Mccartney, D., Stevenson, A., Walker, R., Gibson, J., Morris, S. W., Campbell, A., Murray, A. D., Whalley, H., Porteous, D., McIntosh, A., Evans, K., Deary, I., & Marioni, R. (2018). Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer’s disease. Alzheimer's & Dementia: The Journal of the Alzheimer's Association. Advance online publication. https://doi.org/10.1016/j.dadm.2018.05.006

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title = "Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer{\textquoteright}s disease",

abstract = "Introduction The “epigenetic clock” is a DNA methylation–based estimate of biological age and is correlated with chronological age—the greatest risk factor for Alzheimer's disease (AD). Genetic and environmental risk factors exist for AD, several of which are potentially modifiable. In this study, we assess the relationship between the epigenetic clock and AD risk factors. Methods Multilevel models were used to assess the relationship between age acceleration (the residual of biological age regressed onto chronological age) and AD risk factors relating to cognitive reserve, lifestyle, disease, and genetics in the Generation Scotland study (n = 5100). Results We report significant associations between the epigenetic clock and body mass index, total cholesterol to high-density lipoprotein cholesterol ratios, socioeconomic status, high blood pressure, and smoking behavior (Bonferroni-adjusted P < .05). Discussion Associations are present between environmental risk factors for AD and age acceleration. Measures to modify such risk factors might improve the risk profile for AD and the rate of biological ageing. Future longitudinal analyses are therefore warranted.",

author = "Daniel Mccartney and Anna Stevenson and Rosie Walker and Jude Gibson and Morris, {Stewart W} and Archibald Campbell and Murray, {Alison D.} and Heather Whalley and David Porteous and Andrew McIntosh and Kathryn Evans and Ian Deary and Riccardo Marioni",

year = "2018",

month = jun,

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doi = "10.1016/j.dadm.2018.05.006",

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Mccartney, D, Stevenson, A, Walker, R, Gibson, J, Morris, SW, Campbell, A, Murray, AD, Whalley, H, Porteous, D, McIntosh, A , Evans, K , Deary, I & Marioni, R 2018, 'Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer’s disease', Alzheimer's & Dementia: The Journal of the Alzheimer's Association. https://doi.org/10.1016/j.dadm.2018.05.006

TY - JOUR

T1 - Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer’s disease

AU - Mccartney, Daniel

AU - Stevenson, Anna

AU - Walker, Rosie

AU - Gibson, Jude

AU - Morris, Stewart W

AU - Campbell, Archibald

AU - Murray, Alison D.

AU - Whalley, Heather

AU - Porteous, David

AU - McIntosh, Andrew

AU - Evans, Kathryn

AU - Deary, Ian

AU - Marioni, Riccardo

PY - 2018/6/21

Y1 - 2018/6/21

N2 - Introduction The “epigenetic clock” is a DNA methylation–based estimate of biological age and is correlated with chronological age—the greatest risk factor for Alzheimer's disease (AD). Genetic and environmental risk factors exist for AD, several of which are potentially modifiable. In this study, we assess the relationship between the epigenetic clock and AD risk factors. Methods Multilevel models were used to assess the relationship between age acceleration (the residual of biological age regressed onto chronological age) and AD risk factors relating to cognitive reserve, lifestyle, disease, and genetics in the Generation Scotland study (n = 5100). Results We report significant associations between the epigenetic clock and body mass index, total cholesterol to high-density lipoprotein cholesterol ratios, socioeconomic status, high blood pressure, and smoking behavior (Bonferroni-adjusted P < .05). Discussion Associations are present between environmental risk factors for AD and age acceleration. Measures to modify such risk factors might improve the risk profile for AD and the rate of biological ageing. Future longitudinal analyses are therefore warranted.

AB - Introduction The “epigenetic clock” is a DNA methylation–based estimate of biological age and is correlated with chronological age—the greatest risk factor for Alzheimer's disease (AD). Genetic and environmental risk factors exist for AD, several of which are potentially modifiable. In this study, we assess the relationship between the epigenetic clock and AD risk factors. Methods Multilevel models were used to assess the relationship between age acceleration (the residual of biological age regressed onto chronological age) and AD risk factors relating to cognitive reserve, lifestyle, disease, and genetics in the Generation Scotland study (n = 5100). Results We report significant associations between the epigenetic clock and body mass index, total cholesterol to high-density lipoprotein cholesterol ratios, socioeconomic status, high blood pressure, and smoking behavior (Bonferroni-adjusted P < .05). Discussion Associations are present between environmental risk factors for AD and age acceleration. Measures to modify such risk factors might improve the risk profile for AD and the rate of biological ageing. Future longitudinal analyses are therefore warranted.

U2 - 10.1016/j.dadm.2018.05.006

DO - 10.1016/j.dadm.2018.05.006

M3 - Article

SN - 1552-5260

JO - Alzheimer's & Dementia: The Journal of the Alzheimer's Association

JF - Alzheimer's & Dementia: The Journal of the Alzheimer's Association

ER -

Investigating the relationship between DNA methylation age acceleration and risk factors for Alzheimer’s disease

Abstract

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Projects

Omics prediction of Alzheimer's disease

Stratifying Resilience and Depression Longitudinally

MRC Dementias Platform

Cite this