Investigating the rigour of research findings in experimental studies assessing the effects of breaking up prolonged sitting – extended scoping review

Coralie English, Ishanka Weerasekara, Anjelica Carlos, Sebastien Chastin, Gary Crowfoot, Claire Fitzsimons, Anne Forster, Elizabeth Holliday, Heidi Janssen, Paul Mackie, Gillian Mead, David Dunstan

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Sedentary behaviour research is a relatively new field, much of which has emergedsince the widespread acceptance of clinical trial registration. The aim of this study was toinvestigate the trial registration and related issues in studies investigating the effect of frequentactivity interruptions to prolonged sitting-time.Methods: Secondary analysis of a scoping review including systematic searches of databases andtrial registries. We included experimental studies investigating the effects of frequent activityinterruptions to prolonged sitting-time.
Results: We identified 32 trials published in 45 papers. Only 16 (50%) trials were registered, withall 16 trials being completed and published. Of the unregistered trials, we identified three (19%)for which similarities in the sample size and participant demographics across papers was sug-gestive of duplicate publication. Identification of potential duplicate publications was difficultfor the remaining 13 (81%). Results from 53 (76%) of the 70 registered outcomes were published,but 11 (69%) registered trials reported results from additional outcomes not prospectively regis-tered. A total of 46 different outcomes (out of 53 reported outcome measures, similar measureswere collated) were reported across all trials, 31 (67%) of which were collected in ≤2 trials.Conclusions: We found direct evidence of trial registration issues in experimental trials of break-ing up sitting-time. The lack of prospective registration of all trials, and the large number ofoutcomes measured per trial are key considerations for future research in this field. Theseissues are unlikely to be confined to the field of sedentary behaviour research.
Original languageEnglish
JournalBrazilian Journal of Physical Therapy
Volume25
Issue number1
Early online date15 May 2020
DOIs
Publication statusE-pub ahead of print - 15 May 2020

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