A coupled ice stream-ice shelf-ocean cavity model is used to assess the sensitivity of the coupled system to far-field ocean temperatures, varying from 0.0 to 1.8°C, as well as sensitivity to the parameters controlling grounded ice flow. A response to warming is seen in grounding line retreat and grounded ice loss that cannot be inferred from the response of integrated melt rates alone. This is due to concentrated thinning at the ice shelf lateral margin, and to processes that contribute to this thinning. Parameters controlling the flow of grounded ice have a strong influence on the response to sub-ice shelf melting, but this influence is not seen until several years after an initial perturbation in temperatures. The simulated melt rates are on the order of that observed for Pine Island Glacier in the 1990s. However, retreat rates are much slower, possibly due to unrepresented bedrock features.