@article{5f79513613c94dcab5dc5f3dcb58e55b,
title = "Investigation of microRNA Biomarkers in Equine Distal Interphalangeal Joint Osteoarthritis",
abstract = "Osteoarthritis of the equine distal interphalangeal joint is a common cause of lameness. Mi-croRNAs from biofluids are promising biomarkers and therapeutic candidates. Synovial fluid samples from horses with mild and severe equine distal interphalangeal joint osteoarthritis were submitted for small RNA sequencing. The results demonstrated that miR-92a was downregulated in equine synovial fluid from horses with severe osteoarthritis and there was a significant increase in COMP, COL1A2, RUNX2 and SOX9 following miR-92a mimic treatment of equine chondro-cytes in monolayer culture. This is the first equine study to evaluate the role of miR-92a in oste-oarthritic chondrocytes in vitro.",
keywords = "microRNA, biomarkers, synovial fluid, equine, distal interphalangeal joint, osteoarthritis",
author = "Melissa Baker and Seungmee Lee and Michael Clinton and Matthias Hackl and Catarina Castanheira and Peffers, {Mandy J} and Sarah Taylor",
note = "Funding Information: The authors acknowledge The Horse Trust for funding Melissa Baker{\textquoteright}s Ph.D. scholarship. Thanks to Chandra Logie, Craig Pennycook and Craig Johnstone from the University of Edinburgh for assisting with processing of the equine feet samples. Thanks to Scott Maxwell, Sionagh Smith, Dawn Drummond and Gillian McGregor at Easter Bush Pathology for their help and expertise with the histological sample processing and to the National Research Foundation (NRF) South Africa for part funding the histology costs. Funding Information: Melissa Baker{\textquoteright}s Ph.D. scholarship is generously funded by The Horse Trust (G4018), Seungmee Lee{\textquoteright}s postdoctoral position is funded by the Horseracing Betting Levy Board (Prj 790) and Catarina Castanheira is funded through a Horse Trust PhD studentship (G5018). Mandy Peffers is funded through a Wellcome Trust Clinical Intermediate Fellowship (grant number 107471/Z/15/Z). Publisher Copyright: {\textcopyright} 2022 by the authors.",
year = "2022",
month = dec,
doi = "10.3390/ijms232415526",
language = "English",
volume = "23",
pages = "1--17",
journal = "International Journal of Molecular Sciences",
issn = "1422-0067",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "24",
}