Investigation of microRNA Biomarkers in Equine Distal Interphalangeal Joint Osteoarthritis

Melissa Baker, Seungmee Lee, Michael Clinton, Matthias Hackl, Catarina Castanheira, Mandy J Peffers, Sarah Taylor

Research output: Contribution to journalSpecial issuepeer-review

Abstract / Description of output

Osteoarthritis of the equine distal interphalangeal joint is a common cause of lameness. Mi-croRNAs from biofluids are promising biomarkers and therapeutic candidates. Synovial fluid samples from horses with mild and severe equine distal interphalangeal joint osteoarthritis were submitted for small RNA sequencing. The results demonstrated that miR-92a was downregulated in equine synovial fluid from horses with severe osteoarthritis and there was a significant increase in COMP, COL1A2, RUNX2 and SOX9 following miR-92a mimic treatment of equine chondro-cytes in monolayer culture. This is the first equine study to evaluate the role of miR-92a in oste-oarthritic chondrocytes in vitro.
Original languageEnglish
Article number15526
Pages (from-to)1-17
JournalInternational Journal of Molecular Sciences
Volume23
Issue number24
Early online date8 Dec 2022
DOIs
Publication statusPublished - Dec 2022

Keywords / Materials (for Non-textual outputs)

  • microRNA
  • biomarkers
  • synovial fluid
  • equine
  • distal interphalangeal joint
  • osteoarthritis

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