Abstract / Description of output
Osteoarthritis of the equine distal interphalangeal joint is a common cause of lameness. Mi-croRNAs from biofluids are promising biomarkers and therapeutic candidates. Synovial fluid samples from horses with mild and severe equine distal interphalangeal joint osteoarthritis were submitted for small RNA sequencing. The results demonstrated that miR-92a was downregulated in equine synovial fluid from horses with severe osteoarthritis and there was a significant increase in COMP, COL1A2, RUNX2 and SOX9 following miR-92a mimic treatment of equine chondro-cytes in monolayer culture. This is the first equine study to evaluate the role of miR-92a in oste-oarthritic chondrocytes in vitro.
Keywords / Materials (for Non-textual outputs)
- synovial fluid
- distal interphalangeal joint