Investigation of Pathological Haemorrhage in Maine Coon Cats

Conor O'Halloran, Petra Cerna, Craig Breheny, N. Reed, K. Rolph, S. Cade, J. Jones , R. Brown , S. Slade , K. Papasouliotis, Danielle Gunn-Moore

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Objective: Afibrinogenaemic haemorrhage was previously reported in a Maine Coon cat. Two littermates subsequently died from surgical non-haemostasis, suggesting a hereditable coagulopathy. Methods: We prospectively recruited cats which were: a) Maine Coons with pathological haemorrhage (Group 1, n=8), b) healthy familial relatives of Group 1 (Group 2, n=13) and c) healthy Maine Coons unrelated to Groups 1 and 2 (Group 3, n=12). Coagulation tests: prothrombin time, activated partial thromboplastin time and thrombin clotting time (TCT) were performed on citrated plasma along with quantification of fibrinogen. Routine haematological examination was performed on EDTA-anticoagulated blood collected contemporaneously. Results: Thirty-three blood samples were analysed. Fibrinogen concentrations were significantly reduced in Groups 1 (p<0.01) and 2 (p<0.01) compared to Group 3. Similarly, TCT was found to be significantly extended in Group 1 (p<0.01) and Group 2 (p=0.02) with respect to Group 3. Conclusions and relevance: Dysfibrinogenaemia was identified in clinical cases and their healthy relatives, suggesting that this may represent a hereditary condition of Maine Coon cats. Clinicians should be aware of the increased potential for non-haemostasis in this cat breed and consider assessing clotting function prior to (elective) surgery.
Original languageEnglish
JournalVeterinary Record
Early online date21 Aug 2020
DOIs
Publication statusE-pub ahead of print - 21 Aug 2020

Keywords / Materials (for Non-textual outputs)

  • Maine Coon
  • coagulopathy
  • haemorrhage
  • fibrinogen

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