Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse

K.F. Kitto, J.E. Haley, G.L. Wilcox

Research output: Contribution to journalArticlepeer-review


Intrathecal injection of N-methyl-D-aspartate (NMDA) induces a short duration hyperalgesia in mice. An inhibitor of nitric oxide synthase (NOS), N(ω)-nitro-L-arginine methyl ester (L-NAME), administered either systemically or intrathecally, blocked the NMDA-induced hyperalgesia. This effect was partially reversed by the NOS substrate, L-arginine. Intrathecal hemoglobin mimicked the effects of L-NAME. Intrathecal injection of the NO-donating compounds, sodium nitroprusside (SNP) and hydroxylamine, resulted in a hyperalgesia that lasted 3 h and was reduced by coadministration of hemoglobin. Thus, nitric oxide production appears to mediate NMDA-induced hypersensitivity and may contribute to other forms of centrally induced hyperalgesia.
Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalNeuroscience Letters
Issue number1-2
Publication statusPublished - 1 Jan 1992


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