IQ in childhood and atherosclerosis in middle-age: 40 year follow-up of the newcastle thousand families cohort study

Beverly A. Roberts; G. David Batty; Catharine R. Gale; Ian J. Deary; Louise Parker; Mark S. Pearce

doi:10.1016/j.atherosclerosis.2013.09.018

IQ in childhood and atherosclerosis in middle-age: 40 year follow-up of the newcastle thousand families cohort study

Beverly A. Roberts^*, G. David Batty, Catharine R. Gale, Ian J. Deary, Louise Parker, Mark S. Pearce

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: Carotid intima-media thickness (IMT) is a known precursor to coronary heart disease (CHD) and other relevant health outcomes such as stroke and cognitive impairment. In addition, higher childhood intelligence has been associated with lower risk of coronary heart disease events in later life, although the mechanisms of effect are unclear. We therefore examined the association between childhood intelligence and atherosclerosis using carotid IMT as a marker of the atherosclerotic process.

Approach: Participants were 412 members of the Newcastle Thousand Families Study, a prospective cohort study of all 1142 births in the city of Newcastle in May and June 1947, who took an IQ test and English and arithmetic tests at age 11 years. Study members participated in a medical examination and lifestyle assessment at age 49-51 years during which IMT was measured using ultrasound techniques.

Results: Individuals with higher childhood IQ score had a lower mean IMT in middle-age. A standard deviation higher score in childhood overall IQ was associated with a 0.053 mm (95% CI -0.102, -0.004) lower IMT in men and a 0.039 mm (95% CI -0.080, -0.002) lower IMT in women. Similar levels of association were found for the English and arithmetic tests. After adjustment for a range of covariates including education, the size of effect was undiminished in men but increased in women.

Original language	English
Pages (from-to)	234-237
Number of pages	4
Journal	Atherosclerosis
Volume	231
Issue number	2
Early online date	2 Oct 2013
DOIs	https://doi.org/10.1016/j.atherosclerosis.2013.09.018
Publication status	Published - Dec 2013

Keywords / Materials (for Non-textual outputs)

childhood IQ
atherosclerosis
intima-media thickness
cognitive epidemiology
coronary-heart-disease
premature mortality
1970 British cohort
Vietnam experience
risk factors
carotid atherosclerosis
cardiovascular disease
Aberdeen children
early adulthood

Access to Document

10.1016/j.atherosclerosis.2013.09.018

GALE_IQ_in_Childhood_and_Atherosclerosis_in_Middle_Age
© Roberts, B. A., Batty, G. D., Gale, C. R., Deary, I. J., Parker, L., & Pearce, M. S. (2013). IQ in childhood and atherosclerosis in middle-age: 40 Year follow-up of the Newcastle Thousand Families Cohort Study. Atherosclerosis, 231(2), 234-237. 10.1016/j.atherosclerosis.2013.09.018
Accepted author manuscript, 64 KB
GALE_IQ_in_Childhood_and_Atherosclerosis_in_Middle_Age_Charts
© Roberts, B. A., Batty, G. D., Gale, C. R., Deary, I. J., Parker, L., & Pearce, M. S. (2013). IQ in childhood and atherosclerosis in middle-age: 40 Year follow-up of the Newcastle Thousand Families Cohort Study. Atherosclerosis, 231(2), 234-237. 10.1016/j.atherosclerosis.2013.09.018
Accepted author manuscript, 64 KB

http://www.sciencedirect.com/science/article/pii/S0021915013005649

3 Finished

Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.
Maclullich, A. (Principal Investigator)
1/09/13 → 31/08/19
Project: Research
RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I. (Principal Investigator), Gale, C. (Co-investigator), Holmes, M. (Co-investigator), Logie, P. (Co-investigator), Maclullich, A. (Co-investigator), Porteous, D. (Co-investigator), Seckl, J. (Co-investigator), Starr, J. (Co-investigator), Wardlaw, J. (Co-investigator) & Okely, J. (Researcher)
1/09/13 → 31/08/19
Project: Research
MRC Centre for Cognitive Ageing and Cognitive Epidemiology
Deary, I. (Principal Investigator), Holmes, M. (Co-investigator), Logie, P. (Co-investigator), McCulloch, J. (Co-investigator), Porteous, D. (Co-investigator), Roberts, N. (Co-investigator), Seckl, J. (Co-investigator), Starr, J. (Co-investigator) & Wardlaw, J. (Co-investigator)
MRC
1/09/08 → 31/08/13
Project: Research

1 Paper

IQ in Childhood and Atherosclerosis in Middle-age: 40 year follow-up of the Newcastle Thousand Families Cohort Study
Roberts, B., Batty, G. D., Deary, I., Parker, L., Unwin, N. & Pearce, M. S., 2009.
Research output: Contribution to conference › Paper

Cite this

@article{5f84eaaf62c64dbda91e2b05c43697ee,

title = "IQ in childhood and atherosclerosis in middle-age: 40 year follow-up of the newcastle thousand families cohort study",

abstract = "Objective: Carotid intima-media thickness (IMT) is a known precursor to coronary heart disease (CHD) and other relevant health outcomes such as stroke and cognitive impairment. In addition, higher childhood intelligence has been associated with lower risk of coronary heart disease events in later life, although the mechanisms of effect are unclear. We therefore examined the association between childhood intelligence and atherosclerosis using carotid IMT as a marker of the atherosclerotic process.Approach: Participants were 412 members of the Newcastle Thousand Families Study, a prospective cohort study of all 1142 births in the city of Newcastle in May and June 1947, who took an IQ test and English and arithmetic tests at age 11 years. Study members participated in a medical examination and lifestyle assessment at age 49-51 years during which IMT was measured using ultrasound techniques.Results: Individuals with higher childhood IQ score had a lower mean IMT in middle-age. A standard deviation higher score in childhood overall IQ was associated with a 0.053 mm (95% CI -0.102, -0.004) lower IMT in men and a 0.039 mm (95% CI -0.080, -0.002) lower IMT in women. Similar levels of association were found for the English and arithmetic tests. After adjustment for a range of covariates including education, the size of effect was undiminished in men but increased in women.Conclusions: In the present study, higher childhood IQ scores were associated with a lower degree of atherosclerosis by middle-age. (C) 2013 Elsevier Ireland Ltd. All rights reserved.",

keywords = "childhood IQ, atherosclerosis, intima-media thickness, cognitive epidemiology, coronary-heart-disease, premature mortality, 1970 British cohort, Vietnam experience, risk factors, carotid atherosclerosis, cardiovascular disease, Aberdeen children, early adulthood",

author = "Roberts, {Beverly A.} and Batty, {G. David} and Gale, {Catharine R.} and Deary, {Ian J.} and Louise Parker and Pearce, {Mark S.}",

year = "2013",

month = dec,

doi = "10.1016/j.atherosclerosis.2013.09.018",

language = "English",

volume = "231",

pages = "234--237",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "Elsevier Ireland Ltd",

number = "2",

}

TY - JOUR

T1 - IQ in childhood and atherosclerosis in middle-age

T2 - 40 year follow-up of the newcastle thousand families cohort study

AU - Roberts, Beverly A.

AU - Batty, G. David

AU - Gale, Catharine R.

AU - Deary, Ian J.

AU - Parker, Louise

AU - Pearce, Mark S.

PY - 2013/12

Y1 - 2013/12

N2 - Objective: Carotid intima-media thickness (IMT) is a known precursor to coronary heart disease (CHD) and other relevant health outcomes such as stroke and cognitive impairment. In addition, higher childhood intelligence has been associated with lower risk of coronary heart disease events in later life, although the mechanisms of effect are unclear. We therefore examined the association between childhood intelligence and atherosclerosis using carotid IMT as a marker of the atherosclerotic process.Approach: Participants were 412 members of the Newcastle Thousand Families Study, a prospective cohort study of all 1142 births in the city of Newcastle in May and June 1947, who took an IQ test and English and arithmetic tests at age 11 years. Study members participated in a medical examination and lifestyle assessment at age 49-51 years during which IMT was measured using ultrasound techniques.Results: Individuals with higher childhood IQ score had a lower mean IMT in middle-age. A standard deviation higher score in childhood overall IQ was associated with a 0.053 mm (95% CI -0.102, -0.004) lower IMT in men and a 0.039 mm (95% CI -0.080, -0.002) lower IMT in women. Similar levels of association were found for the English and arithmetic tests. After adjustment for a range of covariates including education, the size of effect was undiminished in men but increased in women.Conclusions: In the present study, higher childhood IQ scores were associated with a lower degree of atherosclerosis by middle-age. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

AB - Objective: Carotid intima-media thickness (IMT) is a known precursor to coronary heart disease (CHD) and other relevant health outcomes such as stroke and cognitive impairment. In addition, higher childhood intelligence has been associated with lower risk of coronary heart disease events in later life, although the mechanisms of effect are unclear. We therefore examined the association between childhood intelligence and atherosclerosis using carotid IMT as a marker of the atherosclerotic process.Approach: Participants were 412 members of the Newcastle Thousand Families Study, a prospective cohort study of all 1142 births in the city of Newcastle in May and June 1947, who took an IQ test and English and arithmetic tests at age 11 years. Study members participated in a medical examination and lifestyle assessment at age 49-51 years during which IMT was measured using ultrasound techniques.Results: Individuals with higher childhood IQ score had a lower mean IMT in middle-age. A standard deviation higher score in childhood overall IQ was associated with a 0.053 mm (95% CI -0.102, -0.004) lower IMT in men and a 0.039 mm (95% CI -0.080, -0.002) lower IMT in women. Similar levels of association were found for the English and arithmetic tests. After adjustment for a range of covariates including education, the size of effect was undiminished in men but increased in women.Conclusions: In the present study, higher childhood IQ scores were associated with a lower degree of atherosclerosis by middle-age. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

KW - childhood IQ

KW - atherosclerosis

KW - intima-media thickness

KW - cognitive epidemiology

KW - coronary-heart-disease

KW - premature mortality

KW - 1970 British cohort

KW - Vietnam experience

KW - risk factors

KW - carotid atherosclerosis

KW - cardiovascular disease

KW - Aberdeen children

KW - early adulthood

U2 - 10.1016/j.atherosclerosis.2013.09.018

DO - 10.1016/j.atherosclerosis.2013.09.018

M3 - Article

SN - 0021-9150

VL - 231

SP - 234

EP - 237

JO - Atherosclerosis

JF - Atherosclerosis

IS - 2

ER -

IQ in childhood and atherosclerosis in middle-age: 40 year follow-up of the newcastle thousand families cohort study

Abstract

Keywords / Materials (for Non-textual outputs)

Access to Document

Fingerprint

Projects

Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.

RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.

MRC Centre for Cognitive Ageing and Cognitive Epidemiology

Research output

IQ in Childhood and Atherosclerosis in Middle-age: 40 year follow-up of the Newcastle Thousand Families Cohort Study

Cite this