Irinotecan metabolite SN38 results in germ cell loss in the testis but not in the ovary of prepubertal mice

Federica Lopes; Rowena Smith; Sophie Nash; Rod T. Mitchell; Norah Spears

doi:10.1093/molehr/gaw051

Irinotecan metabolite SN38 results in germ cell loss in the testis but not in the ovary of prepubertal mice

Federica Lopes, Rowena Smith, Sophie Nash, Rod T. Mitchell, Norah Spears

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	gaw051
Journal	Molecular Human Reproduction
Early online date	28 Jul 2016
DOIs	https://doi.org/10.1093/molehr/gaw051
Publication status	E-pub ahead of print - 28 Jul 2016

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10.1093/molehr/gaw051

Lopes 2016 - Ironotecan
This is an author-produced document of an article accepted for publication in Molecular Human Reproduction following peer review. The definitive publisher-authenticated version is available online at: http://molehr.oxfordjournals.org/cgi/content/abstract/gaw051?ijkey=1nBZ73Y9VQKziSS&keytype=ref
Accepted author manuscript, 1.63 MBLicence: Creative Commons: Attribution (CC-BY)

http://www.molehr.oxfordjournals.org/lookup/doi/10.1093/molehr/gaw051

2 Finished

Fertility preservation in pre-pubertal boys treated for cancer during childhood
Spears, N. & Mitchell, R.
UK-based charities
11/01/16 → 10/07/19
Project: Research
Systematic investigation of the effect of chemotherapeutic agents on the ovary using ovarian follicle culture systems
Spears, N., Anderson, R., Gourley, C. & Telfer, E.
MRC
26/09/11 → 31/12/14
Project: Research

Norah Spears
- Deanery of Biomedical Sciences - Personal Chair of Reproductive Physiology
- Centre for Discovery Brain Sciences
Person: Academic: Research Active

Cite this

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title = "Irinotecan metabolite SN38 results in germ cell loss in the testis but not in the ovary of prepubertal mice",

author = "Federica Lopes and Rowena Smith and Sophie Nash and Mitchell, {Rod T.} and Norah Spears",

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T1 - Irinotecan metabolite SN38 results in germ cell loss in the testis but not in the ovary of prepubertal mice

AU - Lopes, Federica

AU - Smith, Rowena

AU - Nash, Sophie

AU - Mitchell, Rod T.

AU - Spears, Norah

PY - 2016/7/28

Y1 - 2016/7/28

U2 - 10.1093/molehr/gaw051

DO - 10.1093/molehr/gaw051

M3 - Article

SP - gaw051

JO - Molecular Human Reproduction

JF - Molecular Human Reproduction

SN - 1360-9947

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Irinotecan metabolite SN38 results in germ cell loss in the testis but not in the ovary of prepubertal mice

Access to Document

Projects

Fertility preservation in pre-pubertal boys treated for cancer during childhood

Systematic investigation of the effect of chemotherapeutic agents on the ovary using ovarian follicle culture systems

Profiles

Norah Spears

Cite this