Iron-catalysed alkene hydrogenation and reductive cross-coupling using a bench-stable iron(II) pre-catalyst

Dominik J. Frank, Lea Guiet, Alexander Kaeslin, Elliot Murphy, Stephen P. Thomas

Research output: Contribution to journalArticlepeer-review

Abstract

Operationally simple, iron-catalysed hydrogenation and reductive cross-coupling protocols have been developed using a bench-stable iron(II) pre-catalyst. The hydrogenation of 18 alkenes (50-99%) and reductive cross-coupling of vinyl halides with aryl- and alkyl Grignard reagents (8 examples, 18-99%) is reported using 3 mol% pre-catalyst and hydrogen as stoichiometric reductant (1-50 bar).

Original languageEnglish
Pages (from-to)25698-25701
Number of pages4
JournalRSC Advances
Volume3
Issue number48
Early online date23 Oct 2013
DOIs
Publication statusPublished - 28 Dec 2013

Keywords

  • ARYL GRIGNARD-REAGENTS
  • ALKYL-HALIDES
  • COMPLEXES
  • DERIVATIVES
  • SCALE

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