Iron‐catalysed C(sp2)‐H Borylation with Expanded Functional Group Tolerance

Luke Britton, Jamie H. Docherty, Gary S. Nichol, Andrew P. Dominey, Stephen P. Thomas

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Arene C(sp2)-H bond borylation offers direct and efficient access to aryl boronic esters. Using in situ catalyst activation and photoirradiation, the iron-catalysed C(sp2)-H borylation reaction of carboarenes, pyrroles, and indoles has been developed using only bench-stable pre-catalysts and reagents. Good functional group tolerance was observed including those not tolerated under previous methods (ArNH2, ArOH, ArSiR3, ArP(O)(OR)2, ArC(O)NR2). Mechanistic studies revealed iron-catalysed reductive deoxygenation, C-F protodefluorination, and a demethylation of aryl methyl ethers by C-O sigma bond hydroboration.
Original languageEnglish
JournalChinese Journal of Chemistry
Early online date7 Sept 2022
DOIs
Publication statusE-pub ahead of print - 7 Sept 2022

Keywords / Materials (for Non-textual outputs)

  • Boron
  • C-H borylation
  • Earth-abundant
  • Iron
  • Photochemistry

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