Is 1 alanine transaminase >200 IU enough to define an alanine transaminase flare in HIV-infected populations? A new definition derived from a large cohort study

UK Collaborative HIV Cohort Study, Loveleen Bansi, Jo Turner, Richard Gilson, Frank Post, Brian Gazzard, Clifford Leen, Jane Anderson, Kholoud Porter, Teresa Hill, Martin Fisher, Jonathan Ainsworth, Deenan Pillay, Margaret Johnson, Alan Winston, Chloe Orkin, Philippa Easterbrook, Andrew Phillips, Caroline Sabin

Research output: Contribution to journalArticlepeer-review

Abstract

Recent studies have suggested that highly active antiretroviral therapy may lead to rises in alanine transaminase (ALT) among HIV-infected patients. However, the definition of an ALT flare is arbitrary and the extent to which such increases represent normal fluctuations has not been explored.
Original languageEnglish
Pages (from-to)391-6
Number of pages6
JournalJournal of Acquired Immune Deficiency Syndromes
Volume52
Issue number3
DOIs
Publication statusPublished - 1 Nov 2009

Keywords

  • Adult
  • Alanine Transaminase
  • Anti-HIV Agents
  • Antiretroviral Therapy, Highly Active
  • Cohort Studies
  • Female
  • HIV Infections
  • Hepatitis B
  • Hepatitis C
  • Humans
  • Male

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