Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome?

Talakad G Lohith, Emily K Osterweil, Masahiro Fujita, Kimberly J Jenko, Mark F Bear, Robert B Innis

Research output: Contribution to journalArticlepeer-review

Abstract

Fragile X syndrome (FXS) is a common inherited form of intellectual disability caused by loss of function of the fragile X mental retardation protein. Recent animal studies suggest that upregulated downstream signaling by metabotropic glutamate receptor 5 (mGluR5) might be an important mechanism for cognitive and behavioral abnormalities associated with FXS. However, mGluR5 density in human FXS remains unknown.
Original languageEnglish
Pages (from-to)15
JournalMolecular Autism
Volume4
Issue number1
DOIs
Publication statusPublished - 2013

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