Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome?

Talakad G Lohith; Emily K Osterweil; Masahiro Fujita; Kimberly J Jenko; Mark F Bear; Robert B Innis

doi:10.1186/2040-2392-4-15

Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome?

Talakad G Lohith, Emily K Osterweil, Masahiro Fujita, Kimberly J Jenko, Mark F Bear, Robert B Innis

Deanery of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Fragile X syndrome (FXS) is a common inherited form of intellectual disability caused by loss of function of the fragile X mental retardation protein. Recent animal studies suggest that upregulated downstream signaling by metabotropic glutamate receptor 5 (mGluR5) might be an important mechanism for cognitive and behavioral abnormalities associated with FXS. However, mGluR5 density in human FXS remains unknown.

Original language	English
Pages (from-to)	15
Journal	Molecular Autism
Volume	4
Issue number	1
DOIs	https://doi.org/10.1186/2040-2392-4-15
Publication status	Published - 2013

Access to Document

10.1186/2040-2392-4-15

Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome
© 2013 Lohith et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Final published version, 287 KB

http://www.molecularautism.com/content/4/1/15

Cite this

@article{7479de5f7806476c8993aa256747f0df,

title = "Is metabotropic glutamate receptor 5 upregulated in prefrontal cortex in fragile X syndrome?",

abstract = "Fragile X syndrome (FXS) is a common inherited form of intellectual disability caused by loss of function of the fragile X mental retardation protein. Recent animal studies suggest that upregulated downstream signaling by metabotropic glutamate receptor 5 (mGluR5) might be an important mechanism for cognitive and behavioral abnormalities associated with FXS. However, mGluR5 density in human FXS remains unknown.",

author = "Lohith, {Talakad G} and Osterweil, {Emily K} and Masahiro Fujita and Jenko, {Kimberly J} and Bear, {Mark F} and Innis, {Robert B}",

year = "2013",

doi = "10.1186/2040-2392-4-15",

language = "English",

volume = "4",

pages = "15",

journal = "Molecular Autism",

issn = "2040-2392",