Is socioeconomic deprivation associated with worse quality of life, anxiety and depression in liver transplant recipients? A cross-sectional study in a national transplantation programme

Alessandro Sgro, W. A. Cambridge, K. A. Mclean, T. M. Drake, J. Camilleri-Brennan, Stephen Knight, Riinu Pius, D A Wu, Stephen J Wigmore, Ewen M Harrison

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Objective
To identify whether socioeconomic deprivation is associated with worse health-related quality of life (HR-QoL), anxiety, depression following liver transplantation.
Design
Cross-sectional study.
Setting and participants
Liver transplant recipients within a national transplantation programme.
Methods
Participants completed the condition-specific 'Short form of liver disease QOL' questionnaire, the Generalised Anxiety Disorder Questionnaire (GAD-7) and the Patient Health Questionnaire (PHQ-9). The aggregate HR-QoL score (range: 0-100) was derived and multivariable linear regression performed based on sociodemographic and clinical variables to estimate its independent association with Scottish Index of Multiple Deprivation (SIMD) quintiles. The GAD-7 and PHQ-9 questionnaires were used to screen respondents for anxiety and depression, and multivariable logistic regression performed to estimate their independent association with SIMD quintiles.
Results
Some 331 patients completed the questionnaires. Quintiles were equally distributed in the cohort, with no significant differences observed in underlying patient characteristics. Following multivariable adjustment, greater socioeconomic deprivation was associated with lower post-transplantation HR-QoL scores, with a difference of 9.7 points (95%CI: 4.6-14.9, p<0.001) between the most and least deprived quintiles. Recipients living in areas of least deprivation were less likely to suffer from anxiety (OR 0.05, 95%CI: 0.00-0.28, p=0.003) or depression (OR 0.13, 95%CI: 0.02-0.56, p=0.009).
Conclusion
Despite the highly selected nature of liver transplant recipients, those living in the most deprived areas have a significantly lower HR-QoL and are more likely to suffer from anxiety and depression.
Original languageEnglish
Article numbere070422
Number of pages10
JournalBMJ Open
Volume13
Issue number8
DOIs
Publication statusPublished - 9 Aug 2023

Keywords / Materials (for Non-textual outputs)

  • socioeconomic factors
  • liver clinical outcome
  • quality of life

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