Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland?

Geoff Der, G David Batty, Michaela Benzeval, Ian J Deary, Michael J Green, Liane McGlynn, Alan McIntyre, Tony Robertson, Paul G Shiels

Research output: Contribution to journalArticlepeer-review

Abstract

The search for biomarkers of aging (BoAs) has been largely unsuccessful to-date and there is widespread skepticism about the prospects of finding any that satisfy the criteria developed by the American Federation of Aging Research. This may be because the criteria are too strict or because a composite measure might be more appropriate. Telomere length has attracted a great deal of attention as a candidate BoA. We investigate whether it meets the criteria to be considered as a single biomarker of aging, and whether it makes a useful contribution to a composite measure.
Original languageEnglish
Pages (from-to)e45166
JournalPLoS ONE
Volume7
Issue number9
DOIs
Publication statusPublished - 2012

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aging
  • Biological Markers
  • Cognition
  • Cross-Sectional Studies
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Principal Component Analysis
  • Scotland
  • Telomere
  • Telomere Homeostasis

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