Is there a relationship between HLA type and prognostic factors in breast cancer?

C Gourley, C Thornton, C Massie, R J Prescott, M Turner, R C F Leonard, D C Kilpatrick

Research output: Contribution to journalArticlepeer-review

Abstract

No convincing association exists between HLA type and breast cancer development but certain HLA types have been suggested to be associated with poor risk disease. Here, the HLA type (class I and II) for 141 breast cancer patients was compared to a control population of 100 individuals and to the prognostic indicators for the patients. No association was found between HLA type and breast cancer development. Consideration of individual HLA/prognostic factor relationships previously reported confirmed that HLA-B7 was over-represented in premenopausal oestrogen-receptor (ER)-positive, grade 3 tumours (p = 0.04) and that HLA-A1 correlated positively with Nottingham Prognostic Index (p
Original languageEnglish
Pages (from-to)633-8
Number of pages6
JournalAnticancer research
Volume23
Issue number1B
Publication statusPublished - 2003

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Breast Neoplasms
  • Case-Control Studies
  • Female
  • HLA-A Antigens
  • HLA-B Antigens
  • HLA-DR Antigens
  • Humans
  • Middle Aged
  • Prognosis
  • Receptors, Estrogen

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