Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease

Nicholas L Mills; Håkan Törnqvist; Manuel C Gonzalez; Elen Vink; Simon D Robinson; Stefan Söderberg; Nicholas A Boon; Ken Donaldson; Thomas Sandström; Anders Blomberg; David E Newby

doi:10.1056/NEJMoa066314

Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease

Nicholas L Mills, Håkan Törnqvist, Manuel C Gonzalez, Elen Vink, Simon D Robinson, Stefan Söderberg, Nicholas A Boon, Ken Donaldson, Thomas Sandström, Anders Blomberg, David E Newby

Research output: Contribution to journal › Article › peer-review

Abstract

Exposure to air pollution from traffic is associated with adverse cardiovascular events. The mechanisms for this association are unknown. We conducted a controlled exposure to dilute diesel exhaust in patients with stable coronary heart disease to determine the direct effect of air pollution on myocardial, vascular, and fibrinolytic function.

Original language	English
Pages (from-to)	1075-82
Number of pages	8
Journal	New England Journal of Medicine
Volume	357
Issue number	11
DOIs	https://doi.org/10.1056/NEJMoa066314
Publication status	Published - 2007

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Mills, Nicholas L ; Törnqvist, Håkan ; Gonzalez, Manuel C ; Vink, Elen ; Robinson, Simon D ; Söderberg, Stefan ; Boon, Nicholas A ; Donaldson, Ken ; Sandström, Thomas ; Blomberg, Anders ; Newby, David E. / Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease. In: New England Journal of Medicine. 2007 ; Vol. 357, No. 11. pp. 1075-82.

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title = "Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease",

abstract = "Exposure to air pollution from traffic is associated with adverse cardiovascular events. The mechanisms for this association are unknown. We conducted a controlled exposure to dilute diesel exhaust in patients with stable coronary heart disease to determine the direct effect of air pollution on myocardial, vascular, and fibrinolytic function.",

author = "Mills, {Nicholas L} and H{\aa}kan T{\"o}rnqvist and Gonzalez, {Manuel C} and Elen Vink and Robinson, {Simon D} and Stefan S{\"o}derberg and Boon, {Nicholas A} and Ken Donaldson and Thomas Sandstr{\"o}m and Anders Blomberg and Newby, {David E}",

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pages = "1075--82",

journal = "New England Journal of Medicine",

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Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease. / Mills, Nicholas L; Törnqvist, Håkan; Gonzalez, Manuel C; Vink, Elen; Robinson, Simon D; Söderberg, Stefan; Boon, Nicholas A; Donaldson, Ken; Sandström, Thomas; Blomberg, Anders; Newby, David E.

In: New England Journal of Medicine, Vol. 357, No. 11, 2007, p. 1075-82.

Research output: Contribution to journal › Article › peer-review

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T1 - Ischemic and thrombotic effects of dilute diesel-exhaust inhalation in men with coronary heart disease

AU - Mills, Nicholas L

AU - Törnqvist, Håkan

AU - Gonzalez, Manuel C

AU - Vink, Elen

AU - Robinson, Simon D

AU - Söderberg, Stefan

AU - Boon, Nicholas A

AU - Donaldson, Ken

AU - Sandström, Thomas

AU - Blomberg, Anders

AU - Newby, David E

PY - 2007

Y1 - 2007

N2 - Exposure to air pollution from traffic is associated with adverse cardiovascular events. The mechanisms for this association are unknown. We conducted a controlled exposure to dilute diesel exhaust in patients with stable coronary heart disease to determine the direct effect of air pollution on myocardial, vascular, and fibrinolytic function.

AB - Exposure to air pollution from traffic is associated with adverse cardiovascular events. The mechanisms for this association are unknown. We conducted a controlled exposure to dilute diesel exhaust in patients with stable coronary heart disease to determine the direct effect of air pollution on myocardial, vascular, and fibrinolytic function.

U2 - 10.1056/NEJMoa066314

DO - 10.1056/NEJMoa066314

M3 - Article

C2 - 17855668

VL - 357

SP - 1075

EP - 1082

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 11

ER -