Projects per year
Abstract / Description of output
models for ISGylation. By regulating EGFR trafficking, ISGylation enhances EGFR recycling and sustains Akt-signalling. We further show that Akt signalling positively correlates with levels of ISG15 and its E2-ligase in basal breast cancer cohorts, confirming the link between ISGylation and Akt signalling in human tumours. Persistent and enhanced Akt activation explains the more aggressive
tumour behaviour observed in human breast cancers. We show that ISGylation can act as a driver of tumour progression rather than merely being a bystander.
Original language | English |
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Journal | Oncogene |
Early online date | 23 Sept 2021 |
DOIs | |
Publication status | E-pub ahead of print - 23 Sept 2021 |
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Dive into the research topics of 'ISGylation drives basal breast tumour progression by promoting EGFR recycling and Akt signalling'. Together they form a unique fingerprint.Projects
- 3 Finished
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Expoiting adhesion protein networks in glioblastoma
Frame, M., Brunton, V., Byron, A. & Pollard, S.
1/05/18 → 30/04/23
Project: Research
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High resolution metabolite and peptide mass spectrometry
Von Kriegsheim, A., Christophorou, M., Finch, A., Morton, N., Ponting, C. & Walmsley, S.
2/10/17 → 1/11/22
Project: Research
Equipment
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Advanced Imaging Resource
Ann Wheeler (Manager), Laura Murphy (Other), Martin Lee (Other), Helen Caldwell (Other), Matthew Pearson (Other) & James Iremonger (Other)
Deanery of Molecular, Genetic and Population Health SciencesFacility/equipment: Facility
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Edinburgh Drug Discovery
Asier Unciti-Broceta (Manager), Scott Webster (Manager) & Neil Carragher (Manager)
Deanery of Molecular, Genetic and Population Health SciencesFacility/equipment: Facility
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Host and Tumour Profiling Unit (HTPU) Microarray Services
Alison Munro (Manager) & Kenneth Macleod (Other)
Deanery of Molecular, Genetic and Population Health SciencesFacility/equipment: Facility