Ising-model description of long-range correlations in DNA sequences

A. Colliva*, R. Pellegrini, A. Testori, M. Caselle

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We model long-range correlations of nucleotides in the human DNA sequence using the long-range one-dimensional (1D) Ising model. We show that, for distances between 10(3) and 10(6) bp, the correlations show a universal behavior and may be described by the non-mean-field limit of the long-range 1D Ising model. This allows us to make some testable hypothesis on the nature of the interaction between distant portions of the DNA chain which led to the DNA structure that we observe today in higher eukaryotes.

Original languageEnglish
Article number052703
Number of pages8
JournalPhysical Review E - Statistical, Nonlinear and Soft Matter Physics
Volume91
Issue number5
DOIs
Publication statusPublished - 8 May 2015

Keywords

  • TRANSPOSABLE ELEMENTS
  • HUMAN GENOME
  • DISTRIBUTIONS
  • EVOLUTION
  • DYNAMICS

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