Projects per year
Abstract / Description of output
AIMS/HYPOTHESIS: Type 1 diabetes complicated by hypoglycaemia is prevalent in socioeconomically deprived populations. Islet transplantation is of proven efficacy in type 1 diabetes complicated by hypoglycaemia, but it is not known if nationally funded programmes reach the socioeconomically deprived. Our aim was to determine: (1) socioeconomic indices in participants referred to our nationally funded programme; and (2) if metabolic outcomes in our transplant recipients were improved.
METHODS: Participants referred (n = 106) and receiving transplants (n = 18; 32 infusions) were examined with respect to socioeconomic status (deprivation category score) and their ability to work and drive. In participants followed for ≥12 months after transplantation, metabolic and anthropometric measurements (n = 14) were recorded pre- and post-transplant (assessed ~1, ~3, ~6 and ~12 months with mixed-meal tolerance tests and 6 day continuous glucose monitoring assessments). Donor data was also examined.
RESULTS: There was a greater prevalence of socioeconomic deprivation in referred and transplant recipients than the general population (p < 0.05). Of the transplant recipients, 73% were socioeconomically deprived, 88% did not hold a driver's license and 94% had reduced ability to work (all p < 0.01 vs referred participants). Donors were predominantly obese and included circulatory death donors. At 12 months, 93% of participants who had received transplants had graft function, diminished frequency of hypoglycaemia (10 [4-11] vs 0 [0-2] hypoglycaemic episodes/week), improved awareness of hypoglycaemia (Gold score 7 [5-7] vs 1 [1-2]) and glycaemic control (HbA1c: 7.9% [7.2-8.5%]; 63 [55-69] mmol/mol vs 7.2% [6.8-7.5%]; 55 [51-58] mmol/mol), diminished glycaemic lability and decreased central adiposity (all p < 0.05).
CONCLUSIONS/INTERPRETATION: A nationally funded islet transplant programme reaches the socioeconomically deprived and outcomes are significantly improved in this group.
Original language | English |
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Pages (from-to) | 1300-1308 |
Journal | Diabetologia |
Volume | 58 |
Issue number | 6 |
Early online date | 26 Mar 2015 |
DOIs | |
Publication status | Published - Jun 2015 |
Keywords / Materials (for Non-textual outputs)
- Islet transplantation
Fingerprint
Dive into the research topics of 'Islet transplantation from a nationally funded UK centre reaches socially deprived groups and improves metabolic outcomes'. Together they form a unique fingerprint.Projects
- 1 Finished
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Optimising islet cell engraftment for long term function in Type 1 Diabetes
1/05/14 → 31/10/17
Project: Research
Research output
- 1 Article
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Attainment of Metabolic Goals in the Integrated UK Islet Transplant Program With Locally Isolated and Transported Preparations
Brooks, A. M., Walker, N., Aldibbiat, A., Hughes, S., Jones, G., de Havilland, J., Choudhary, P., Huang, G. C., Parrott, N., McGowan, N. W. A., Casey, J., Mumford, L., Barker, P., Burling, K., Hovorka, R., Walker, M., Smith, R. M., Forbes, S., Rutter, M. K., Amiel, S., & 3 others , Dec 2013, In: American Journal of Transplantation. 13, 12, p. 3236-3243 8 p.Research output: Contribution to journal › Article › peer-review
Profiles
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Shareen Forbes
- Deanery of Clinical Sciences - Personal Chair of Diabetic Medicine
- Centre for Cardiovascular Science
Person: Academic: Research Active