Isozymes delta of phosphoinositide-specific phospholipase C and their role in signal transduction in the cell

Anna-Maria Ochocka, Tadeusz Pawelczyk

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Phospholipase C (PLC, EC 3.1.4.11) is an enzyme crucial for the phosphoinositol pathway and whose activity is involved in eukaryotic signal transduction as it generates two second messengers: diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). There are four major types of phospholipase C named: beta, gamma, delta and the recently discovered epsilon, but this review will focus only on the recent advances for the delta isozymes of PLC. So far, four delta isozymes (named delta1-4) have been discovered and examined. They differ with regard to cellular distribution, activities, biochemical features and involvement in human ailments.

Original languageEnglish
Pages (from-to)1097-110
Number of pages14
JournalActa biochimica Polonica
Volume50
Issue number4
DOIs
Publication statusPublished - 2003

Keywords

  • Active Transport, Cell Nucleus
  • Animals
  • Cattle
  • Enzyme Activators
  • Enzyme Inhibitors
  • Humans
  • Isoenzymes
  • Phosphoinositide Phospholipase C
  • Phospholipase C delta
  • Phosphoric Diester Hydrolases
  • Protein Sorting Signals
  • Rats
  • Signal Transduction

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