Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

G Melino; E Gallagher; Rami I Aqeilan; R Knight; A Peschiaroli; M Rossi; Flavia Scialpi; M Malatesta; L Zocchi; G Browne; A Ciechanover; F Bernassola

doi:10.1038/cdd.2008.60

Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

G Melino, E Gallagher, Rami I Aqeilan, R Knight, A Peschiaroli, M Rossi, Flavia Scialpi, M Malatesta, L Zocchi, G Browne, A Ciechanover, F Bernassola

Edinburgh Cancer Research Centre

Research output: Contribution to journal › Article › peer-review

Abstract

The HECT-type E3 ubiquitin ligase (E3) Itch is absent in the non-agouti-lethal 18H or Itchy mice, which develop a severe immunological disease, including lung and stomach inflammation and hyperplasia of lymphoid and hematopoietic cells. The involvement of Itch in multiple signaling pathways and pathological conditions is presently an area of extensive scientific interest. This review aims to bring together a growing body of work exploring Itch-regulated biological processes, and to highlight recent discoveries on the regulatory mechanisms modulating its catalytic activity and substrate recognition capability. Our contribution is also an endeavor to correlate Itch substrate specificity with the pathological defects manifested by the mutant Itchy mice.

Original language	English
Pages (from-to)	1103-12
Number of pages	10
Journal	Cell Death & Differentiation (CDD)
Volume	15
Issue number	7
DOIs	https://doi.org/10.1038/cdd.2008.60
Publication status	Published - Jul 2008

Keywords

Animals
Cell Death
Immune System
Keratinocytes
Mice
Mice, Mutant Strains
Neoplasms
Phosphorylation
Protein Transport
Receptor, Epidermal Growth Factor
Receptors, Chemokine
Repressor Proteins
Signal Transduction
Skin
Substrate Specificity
TRPC Cation Channels
Transforming Growth Factor beta
Ubiquitin
Ubiquitin-Protein Ligases

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10.1038/cdd.2008.60

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title = "Itch: a HECT-type E3 ligase regulating immunity, skin and cancer",

abstract = "The HECT-type E3 ubiquitin ligase (E3) Itch is absent in the non-agouti-lethal 18H or Itchy mice, which develop a severe immunological disease, including lung and stomach inflammation and hyperplasia of lymphoid and hematopoietic cells. The involvement of Itch in multiple signaling pathways and pathological conditions is presently an area of extensive scientific interest. This review aims to bring together a growing body of work exploring Itch-regulated biological processes, and to highlight recent discoveries on the regulatory mechanisms modulating its catalytic activity and substrate recognition capability. Our contribution is also an endeavor to correlate Itch substrate specificity with the pathological defects manifested by the mutant Itchy mice.",

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author = "G Melino and E Gallagher and Aqeilan, {Rami I} and R Knight and A Peschiaroli and M Rossi and Flavia Scialpi and M Malatesta and L Zocchi and G Browne and A Ciechanover and F Bernassola",

year = "2008",

month = jul,

doi = "10.1038/cdd.2008.60",

language = "English",

volume = "15",

pages = "1103--12",

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TY - JOUR

T1 - Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

AU - Melino, G

AU - Gallagher, E

AU - Aqeilan, Rami I

AU - Knight, R

AU - Peschiaroli, A

AU - Rossi, M

AU - Scialpi, Flavia

AU - Malatesta, M

AU - Zocchi, L

AU - Browne, G

AU - Ciechanover, A

AU - Bernassola, F

PY - 2008/7

Y1 - 2008/7

N2 - The HECT-type E3 ubiquitin ligase (E3) Itch is absent in the non-agouti-lethal 18H or Itchy mice, which develop a severe immunological disease, including lung and stomach inflammation and hyperplasia of lymphoid and hematopoietic cells. The involvement of Itch in multiple signaling pathways and pathological conditions is presently an area of extensive scientific interest. This review aims to bring together a growing body of work exploring Itch-regulated biological processes, and to highlight recent discoveries on the regulatory mechanisms modulating its catalytic activity and substrate recognition capability. Our contribution is also an endeavor to correlate Itch substrate specificity with the pathological defects manifested by the mutant Itchy mice.

AB - The HECT-type E3 ubiquitin ligase (E3) Itch is absent in the non-agouti-lethal 18H or Itchy mice, which develop a severe immunological disease, including lung and stomach inflammation and hyperplasia of lymphoid and hematopoietic cells. The involvement of Itch in multiple signaling pathways and pathological conditions is presently an area of extensive scientific interest. This review aims to bring together a growing body of work exploring Itch-regulated biological processes, and to highlight recent discoveries on the regulatory mechanisms modulating its catalytic activity and substrate recognition capability. Our contribution is also an endeavor to correlate Itch substrate specificity with the pathological defects manifested by the mutant Itchy mice.

KW - Animals

KW - Cell Death

KW - Immune System

KW - Keratinocytes

KW - Mice

KW - Mice, Mutant Strains

KW - Neoplasms

KW - Phosphorylation

KW - Protein Transport

KW - Receptor, Epidermal Growth Factor

KW - Receptors, Chemokine

KW - Repressor Proteins

KW - Signal Transduction

KW - Skin

KW - Substrate Specificity

KW - TRPC Cation Channels

KW - Transforming Growth Factor beta

KW - Ubiquitin

KW - Ubiquitin-Protein Ligases

U2 - 10.1038/cdd.2008.60

DO - 10.1038/cdd.2008.60

M3 - Article

VL - 15

SP - 1103

EP - 1112

JO - Cell Death & Differentiation (CDD)

JF - Cell Death & Differentiation (CDD)

SN - 1350-9047

IS - 7

ER -

Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

Abstract

Keywords

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