TY - JOUR
T1 - Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL)
T2 - a randomised, double-blind, placebo-controlled trial
AU - Fox, Kim
AU - Ford, Ian
AU - Steg, P Gabriel
AU - Tendera, Michal
AU - Ferrari, Roberto
AU - BEAUTIFUL Investigators
A2 - Murray, Gordon
A2 - Weir, Christopher
PY - 2008
Y1 - 2008
N2 - Ivabradine specifically inhibits the I(f) current in the sinoatrial node to lower heart rate, without affecting other aspects of cardiac function. We aimed to test whether lowering the heart rate with ivabradine reduces cardiovascular death and morbidity in patients with coronary artery disease and left-ventricular systolic dysfunction.
AB - Ivabradine specifically inhibits the I(f) current in the sinoatrial node to lower heart rate, without affecting other aspects of cardiac function. We aimed to test whether lowering the heart rate with ivabradine reduces cardiovascular death and morbidity in patients with coronary artery disease and left-ventricular systolic dysfunction.
U2 - 10.1016/S0140-6736(08)61170-8
DO - 10.1016/S0140-6736(08)61170-8
M3 - Article
C2 - 18757088
SN - 1474-547X
VL - 372
SP - 807
EP - 816
JO - The Lancet
JF - The Lancet
IS - 9641
ER -