@article{16b568ad23ce4bbc863518fe060d19b6,
title = "Key challenges in bringing CRISPR-mediated somatic cell therapy into the clinic",
abstract = "Genome editing using clustered regularly interspersed short palindromic repeats (CRISPR) and CRISPR-associated proteins offers the potential to facilitate safe and effective treatment of genetic diseases refractory to other types of intervention. Here, we identify some of the major challenges for clinicians, regulators, and human research ethics committees in the clinical translation of CRISPR-mediated somatic cell therapy.",
author = "Dianne Nicol and Lisa Eckstein and Michael Morrison and Sherkow, {Jacob S.} and Margaret Otlowski and Tess Whitton and Tania Bubela and Burdon, {Kathryn P.} and Don Chalmers and Sarah Chan and Jac Charlesworth and Christine Critchley and Merlin Crossley and {De Lacey}, Sheryl and Dickinson, {Joanne L.} and Hewitt, {Alex W.} and Joanne Kamens and Kazuto Kato and Erika Kleiderman and Satoshi Kodama and John Liddicoat and Mackey, {David A.} and Newson, {Ainsley J.} and Jane Nielsen and Wagner, {Jennifer K.} and Mcwhirter, {Rebekah E.}",
year = "2017",
month = sep,
day = "25",
doi = "10.1186/s13073-017-0475-4",
language = "English",
volume = "9",
journal = "Genome Medicine",
issn = "1756-994X",
publisher = "BioMed Central",
number = "1",
}