Kin selection explains the evolution of cooperation in the gut microbiota

Camille Simonet, Luke Mcnally

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Through the secretion of “public goods” molecules, microbes cooperatively exploit their habitat. This is known as a major driver of the functioning of microbial communities, including in human disease. Understanding why microbial species cooperate is therefore crucial to achieve successful microbial community management, such as microbiome manipulation. A leading explanation is that of Hamilton’s inclusive-fitness framework. A cooperator can indirectly transmit its genes by helping the reproduction of an individual carrying similar genes. Therefore, all else being equal, as relatedness among individuals increases, so should cooperation. However, the predictive power of relatedness, particularly in microbes, is surrounded by controversy. Using phylogenetic comparative analyses across the full diversity of the human gut microbiota and six forms of cooperation, we find that relatedness is predictive of the cooperative gene content evolution in gut-microbe genomes. Hence, relatedness is predictive of cooperation over broad microbial taxonomic levels that encompass variation in other life-history and ecology details. This supports the generality of Hamilton’s central insights and the relevance of relatedness as a key parameter of interest to advance microbial predictive and engineering science.
Original languageEnglish
Article numbere2016046118
Number of pages10
JournalProceedings of the National Academy of Sciences (PNAS)
Issue number6
Publication statusPublished - 9 Feb 2021

Keywords / Materials (for Non-textual outputs)

  • cooperation
  • comparative analysis
  • microbiome
  • evolutionary microbiology


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