@inbook{f834f78d385b4e87b463ff126d39817d,
title = "Kinetic modelling as a modern technology to explore and modify living cells",
abstract = "We describe a general strategy that enables us to develop kinetic models of large-scale metabolic systems by collecting and using all available metabolic experimental data. Our approach can be used to explore the local and global regulatory properties of selected metabolic pathways, and to predict how cell genome modifications can meet selected biotechnological and biomedical criteria. We have applied the strategy for the development and use of detailed kinetic models of catabolic and anabolic pathways of E. coli and mitochondrial energy metabolism.",
author = "Demin, {Oleg V.} and Galina Lebedeva and Kolupaev, {Alex G} and EA Zobova and Plyusnina, {T Yu} and AI Lavrova and A Dubinsky and EA Goryacheva and Frank Tobin and Igor Goryanin",
year = "2004",
doi = "10.1007/978-3-642-18734-6_4",
language = "English",
isbn = "978-3-642-62269-4",
series = "Natural Computing Series",
publisher = "Springer",
pages = "59--103",
booktitle = "Modelling in Molecular Biology",
address = "United Kingdom",
}