Kinetic modelling of the E. coli metabolism

OlegV. Demin, TatyanaY. Plyusnina, GalinaV. Lebedeva, EkaterinaA. Zobova, EugeniyA. Metelkin, AlexG. Kolupaev, Igor Goryanin, Frank Tobin

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review


We describe a general strategy that enables us to develop kinetic models of large-scale metabolic systems by collecting and using available metabolic and gene regulation experimental data. The approach could be used to explore the local and global regulatory properties of metabolic pathways, and to predict how cell genome modifications can meet specific biotechnological and biomedical criteria. We have successfully applied the strategy for the development and applications of detailed kinetic models of catabolic and anabolic pathways of E. coli.
Original languageEnglish
Title of host publicationSystems Biology
Subtitle of host publicationDefinitions and Perspectives
EditorsLila Alberghina, H.V. Westerhoff
PublisherSpringer Berlin Heidelberg
Number of pages37
Publication statusPublished - 2005

Publication series

NameTopics in Current Genetics
PublisherSpringer Berlin Heidelberg


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