Kinetic modelling of the E. coli metabolism

OlegV. Demin; TatyanaY. Plyusnina; GalinaV. Lebedeva; EkaterinaA. Zobova; EugeniyA. Metelkin; AlexG. Kolupaev; Igor Goryanin; Frank Tobin

doi:10.1007/4735_85

Kinetic modelling of the E. coli metabolism

OlegV. Demin, TatyanaY. Plyusnina, GalinaV. Lebedeva, EkaterinaA. Zobova, EugeniyA. Metelkin, AlexG. Kolupaev, Igor Goryanin, Frank Tobin

School of Informatics

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

Abstract

We describe a general strategy that enables us to develop kinetic models of large-scale metabolic systems by collecting and using available metabolic and gene regulation experimental data. The approach could be used to explore the local and global regulatory properties of metabolic pathways, and to predict how cell genome modifications can meet specific biotechnological and biomedical criteria. We have successfully applied the strategy for the development and applications of detailed kinetic models of catabolic and anabolic pathways of E. coli.

Original language	English
Title of host publication	Systems Biology
Subtitle of host publication	Definitions and Perspectives
Editors	Lila Alberghina, H.V. Westerhoff
Publisher	Springer Berlin Heidelberg
Pages	31-67
Number of pages	37
Volume	13
DOIs	https://doi.org/10.1007/4735_85
Publication status	Published - 2005

Publication series

Name	Topics in Current Genetics
Publisher	Springer Berlin Heidelberg

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10.1007/4735_85

http://dx.doi.org/10.1007/4735_85

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title = "Kinetic modelling of the E. coli metabolism",

abstract = "We describe a general strategy that enables us to develop kinetic models of large-scale metabolic systems by collecting and using available metabolic and gene regulation experimental data. The approach could be used to explore the local and global regulatory properties of metabolic pathways, and to predict how cell genome modifications can meet specific biotechnological and biomedical criteria. We have successfully applied the strategy for the development and applications of detailed kinetic models of catabolic and anabolic pathways of E. coli.",

author = "OlegV. Demin and TatyanaY. Plyusnina and GalinaV. Lebedeva and EkaterinaA. Zobova and EugeniyA. Metelkin and AlexG. Kolupaev and Igor Goryanin and Frank Tobin",

year = "2005",

doi = "10.1007/4735_85",

language = "English",

volume = "13",

series = "Topics in Current Genetics",

publisher = "Springer Berlin Heidelberg",

pages = "31--67",

editor = "Lila Alberghina and H.V. Westerhoff",

booktitle = "Systems Biology",

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Kinetic modelling of the E. coli metabolism. / Demin, OlegV.; Plyusnina, TatyanaY.; Lebedeva, GalinaV. et al.

Systems Biology: Definitions and Perspectives. ed. / Lila Alberghina; H.V. Westerhoff. Vol. 13 Springer Berlin Heidelberg, 2005. p. 31-67 (Topics in Current Genetics).

Research output: Chapter in Book/Report/Conference proceeding › Chapter (peer-reviewed) › peer-review

TY - CHAP

T1 - Kinetic modelling of the E. coli metabolism

AU - Demin, OlegV.

AU - Plyusnina, TatyanaY.

AU - Lebedeva, GalinaV.

AU - Zobova, EkaterinaA.

AU - Metelkin, EugeniyA.

AU - Kolupaev, AlexG.

AU - Goryanin, Igor

AU - Tobin, Frank

PY - 2005

Y1 - 2005

N2 - We describe a general strategy that enables us to develop kinetic models of large-scale metabolic systems by collecting and using available metabolic and gene regulation experimental data. The approach could be used to explore the local and global regulatory properties of metabolic pathways, and to predict how cell genome modifications can meet specific biotechnological and biomedical criteria. We have successfully applied the strategy for the development and applications of detailed kinetic models of catabolic and anabolic pathways of E. coli.

AB - We describe a general strategy that enables us to develop kinetic models of large-scale metabolic systems by collecting and using available metabolic and gene regulation experimental data. The approach could be used to explore the local and global regulatory properties of metabolic pathways, and to predict how cell genome modifications can meet specific biotechnological and biomedical criteria. We have successfully applied the strategy for the development and applications of detailed kinetic models of catabolic and anabolic pathways of E. coli.

U2 - 10.1007/4735_85

DO - 10.1007/4735_85

M3 - Chapter (peer-reviewed)

VL - 13

T3 - Topics in Current Genetics

SP - 31

EP - 67

BT - Systems Biology

A2 - Alberghina, Lila

A2 - Westerhoff, H.V.

PB - Springer Berlin Heidelberg

ER -

Kinetic modelling of the E. coli metabolism

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