Kinetics of the avian influenza-specific humoral responses in lung are indicative of local antibody production

Eveline D. de Geus, Johanna M. J. Rebel, Lonneke Vervelde*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The role and kinetics of respiratory immunoglobulins in AIV infection has not been investigated. In this study we determined the numbers of both total antibody secreting cells (ASC) and virus-specific ASC in lung, spleen, blood and bone marrow (BM) following low-pathogenic AIV infection. Antiviral humoral immune responses were induced both locally in the lung and systemically in the spleen. Responses in the lung and BM preceded responses in the spleen and in blood, with virus-specific IgY ASC already detected in lung and BM from 1 week post-primary inoculation, indicating that respiratory immune responses are not induced in the spleen, but locally in the lung. ASC present in the blood of the lungs and co-isolated during lymphocyte isolation from the lungs have no major impact on the ASC detected in the lungs based on statistical correlation. (C) 2011 Elsevier Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)317-322
Number of pages6
JournalDevelopmental and Comparative Immunology
Volume36
Issue number2
DOIs
Publication statusPublished - Feb 2012

Keywords

  • IMMUNITY
  • TURKEYS
  • Low-pathogenic avian influenza
  • Local
  • Antibody-secreting cell
  • NEWCASTLE-DISEASE VIRUS
  • Humoral immunity
  • SERUM
  • MEMORY B-CELLS
  • HEMAGGLUTININ
  • LYMPHOID-TISSUE
  • VACCINATION
  • INFECTION
  • CHICKENS
  • Systemic
  • Respiratory tract

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