TY - JOUR
T1 - L1 Mosaicism in Mammals
T2 - Extent, Effects, and Evolution
AU - Faulkner, Geoffrey J
AU - Garcia-Perez, Jose L
N1 - Copyright © 2017 The Author(s). Published by Elsevier Ltd.. All rights reserved.
PY - 2017/11/1
Y1 - 2017/11/1
N2 - The retrotransposon LINE-1 (long interspersed element 1, L1) is a transposable element that has extensively colonized the mammalian germline. L1 retrotransposition can also occur in somatic cells, causing genomic mosaicism, as well as in cancer. However, the extent of L1-driven mosaicism arising during ontogenesis is unclear. We discuss here recent experimental data which, at a minimum, fully substantiate L1 mosaicism in early embryonic development and neural cells, including post-mitotic neurons. We also consider the possible biological impact of somatic L1 insertions in neurons, the existence of donor L1s that are highly active ('hot') in specific spatiotemporal niches, and the evolutionary selection of donor L1s driving neuronal mosaicism.
AB - The retrotransposon LINE-1 (long interspersed element 1, L1) is a transposable element that has extensively colonized the mammalian germline. L1 retrotransposition can also occur in somatic cells, causing genomic mosaicism, as well as in cancer. However, the extent of L1-driven mosaicism arising during ontogenesis is unclear. We discuss here recent experimental data which, at a minimum, fully substantiate L1 mosaicism in early embryonic development and neural cells, including post-mitotic neurons. We also consider the possible biological impact of somatic L1 insertions in neurons, the existence of donor L1s that are highly active ('hot') in specific spatiotemporal niches, and the evolutionary selection of donor L1s driving neuronal mosaicism.
KW - Journal Article
KW - Review
U2 - 10.1016/j.tig.2017.07.004
DO - 10.1016/j.tig.2017.07.004
M3 - Review article
C2 - 28797643
SN - 0168-9525
JO - Trends in Genetics
JF - Trends in Genetics
ER -