TY - JOUR
T1 - L1.1 is involved in spinal cord regeneration in adult zebrafish
AU - Becker, Catherina G
AU - Lieberoth, Bettina C
AU - Morellini, Fabio
AU - Feldner, Julia
AU - Becker, Thomas
AU - Schachner, Melitta
PY - 2004
Y1 - 2004
N2 - Adult zebrafish, in contrast to mammals, regrow axons descending from the brainstem after spinal cord transection. L1.1, a homolog of the mammalian recognition molecule L1, is upregulated by brainstem neurons during axon regrowth. However, its functional relevance for regeneration is unclear. Here, we show with a novel morpholino-based approach that reducing L1.1 protein expression leads to impaired locomotor recovery as well as reduced regrowth and synapse formation of axons of supraspinal origin after spinal cord transection. This indicates that L1.1 contributes to successful regrowth of axons from the brainstem and locomotor recovery after spinal cord transection in adult zebrafish.
AB - Adult zebrafish, in contrast to mammals, regrow axons descending from the brainstem after spinal cord transection. L1.1, a homolog of the mammalian recognition molecule L1, is upregulated by brainstem neurons during axon regrowth. However, its functional relevance for regeneration is unclear. Here, we show with a novel morpholino-based approach that reducing L1.1 protein expression leads to impaired locomotor recovery as well as reduced regrowth and synapse formation of axons of supraspinal origin after spinal cord transection. This indicates that L1.1 contributes to successful regrowth of axons from the brainstem and locomotor recovery after spinal cord transection in adult zebrafish.
U2 - 10.1523/JNEUROSCI.2420-04.2004
DO - 10.1523/JNEUROSCI.2420-04.2004
M3 - Article
C2 - 15356195
SN - 1529-2401
VL - 24
SP - 7837
EP - 7842
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 36
ER -