Laboratory diagnosis and molecular epidemiology of an outbreak of hepatitis C virus infection among recipients of human intravenous immunoglobulin in Spain

J M Echevarría, P León, C J Domingo, J A López, C Elola, M Madurga, F Salmerón, P L Yap, J Daub, P Simmonds

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Passive transfer of antibody to hepatitis C virus (HCV) has been thought to occur after infusion of human intravenous immunoglobulin (IVIG), as anti-HCV and/or HCV RNA was commonly found in that product. Recently, however, HCV RNA was detected in the serum of recipients of IVIG. Establishment of a causal relationship between IVIG therapy and HCV infection in recipients was attempted.
Original languageEnglish
Pages (from-to)725-30
Number of pages6
JournalTransfusion
Volume36
Issue number8
DOIs
Publication statusPublished - Aug 1996

Keywords / Materials (for Non-textual outputs)

  • Adolescent
  • Adult
  • Aged
  • Base Sequence
  • Child
  • Female
  • Genotype
  • Hepacivirus
  • Hepatitis C
  • Humans
  • Immunoglobulins, Intravenous
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Polymorphism, Restriction Fragment Length
  • RNA, Viral
  • Spain

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