Lacidipine: Effects on vascular pressor responses throughout the dosage interval in normotensive subjects

Shinichiro Ueda, Richard Donnelly, Vsevolod Panfilov, Andrew D. Morris, Henry L. Elliott*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: To assess the duration and consistency of the pharmacological activity of the dihydropyridine calcium antagonist drug, lacidipine. Methods: Eight healthy normotensive young males participated in a double-blind randomised crossover comparison of single and multiple doses (for 2 weeks) of lacidipine and placebo. The calcium antagonist effects were quantified at 2, 6 and 24 h post dose by the extent of the attenuation of the presser responses to the intravenous administration of the vasoconstrictors angiotensin II and noradrenaline. Results: After 2 weeks of treatment, lacidipine consistently and significantly attenuated the presser responses to both agents at 2 h post dose. At 6 and 24 h post dose there was a significant and progressive decline in the effectiveness of lacidipine in attenuating the presser responses and for the response to angiotensin II there was no statistically significant effect at either 6 or 24 h post dose. Conclusions: These results indicate that there is an obvious 'peak' in the pharmacological activity of lacidipine at about 2 h post dose and that this activity is not fully and consistently maintained throughout 24 h.

Original languageEnglish
Pages (from-to)127-132
Number of pages6
JournalBritish Journal of Clinical Pharmacology
Volume46
Issue number2
DOIs
Publication statusPublished - 4 Aug 1998

Keywords

  • Duration of action
  • Lacidipine
  • Vascular responsiveness
  • Vasoconstrictor agonists

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