Projects per year
Methods: We used two-sample MR to examine the relationship between genetic liability to gallstone disease and circulating levels of bilirubin with CRC in 26,397 patients and 41,481 controls. We calculated the odds ratio per genetically predicted SD unit increase in log bilirubin levels (〖"OR" 〗_"SD" ) for CRC and tested for a non-zero causal effect of gallstones on CRC. Sensitivity analysis was applied to identify violations of estimator assumptions.
Results: No association between either gallstone disease (p-value =0.60) or circulating levels of bilirubin (〖"OR" 〗_"SD" =1.00, 95% confidence interval (CI) =0.96-1.03, p-value =0.90) with CRC was shown.
Conclusions: Despite the large scale of this study we found no evidence for a causal relationship between either circulating levels of bilirubin or gallstone disease with risk of developing CRC. While the magnitude of effect suggested by some observational studies can confidently be excluded, we cannot exclude the possibility of smaller effects sizes and non-linear relationships
Integrative Genomics in Colorectal Cancer Susceptibility:Developing risk reducing interventions through understanding biology
1/01/16 → 28/02/21
1/01/11 → 31/12/15