Lack of association between angiotensin converting enzyme gene insertion deletion polymorphism and stroke

S Ueda, CJ Weir, GC Inglis, GD Murray, KW Muir, KR Lees

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: The human angiotensin converting enzyme (ACE) gene is a candidate genetic locus for stroke because of the importance of the renin-angiotensin system to the development of cardiovascular disease. In the present study, the association between ACE gene deletion/insertion (D/I) polymorphism and the presence or absence of ischaemic stroke was evaluated and possible associations between ACE gene polymorphism and certain subgroups of stroke were investigated.

Materials and methods: DNA samples from 585 unselected suspected stroke patients admitted to the Acute Stroke Unit, Western Infirmary, Glasgow, and from 188 age- and sex-matched controls were genotyped by polymerase chain reaction.

Results: There was no evidence of any association between ACE gene polymorphism and the presence of ischaemic stroke except in the subgroup containing only hypertensive patients, where the odds ratio of a DD genotype for ischaemic stroke was just significantly greater than 1 (odds ratio 2.51, 95% confidence interval 1.06, 5.94). There was no significant association between ACE genotype and the stroke subgroups investigated.

Conclusion: The DD genotype may not be a risk factor for stroke, particularly in the normotensive population. Further study in a strictly controlled population is required to test for the possibility of an increased risk of stroke in hypertensives with DD homozygotes.

Original languageEnglish
Pages (from-to)1597-1601
Number of pages5
JournalJournal of Hypertension
Volume13
Issue number12
Publication statusPublished - Dec 1995
Event7th European Meeting on Hypertension - MILAN, Italy
Duration: 9 Jun 199512 Jun 1995

Keywords

  • angiotensin converting enzyme gene polymorphism
  • stroke
  • HYPERTENSIVE RATS
  • MYOCARDIAL-INFARCTION
  • RENIN
  • HISTORY
  • RISK

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