Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

Hideo Hagihara; Hirotaka Shoji; Satoko Hattori; Giovanni Sala; Yoshihiro Takamiya; Mika Tanaka; Masafumi Ihara; Mihiro Shibutani; Izuho Hatada; Kei Hori; Mikio Hoshino; Akito Nakao; Yasuo Mori; Shigeo Okabe; Masayuki Matsushita; Anja Urbach; Yuta Katayama; Akinobu Matsumoto; Keiichi i Nakayama; Shota Katori; Takuya Sato; Takuji Iwasato; Haruko Nakamura; Yoshio Goshima; Matthieu Raveau; Tetsuya Tatsukawa; Kazuhiro Yamakawa; Noriko Takahashi; Haruo Kasai; Johji Inazawa; Ikuo Nobuhisa; Tetsushi Kagawa; Tetsuya Taga; Mohamed Darwish; Hirofumi Nishizono; Keizo Takao; Kiran Sapkota; Kazutoshi Nakazawa; Tsuyoshi Takagi; Haruki Fujisawa; Yoshihisa Sugimura; Kyosuke Yamanishi; Lakshmi Rajagopal; Nanette deneen Hannah; Herbert y Meltzer; Tohru Yamamoto; Shuji Wakatsuki; Toshiyuki Araki; Katsuhiko Tabuchi; Tadahiro Numakawa; Hiroshi Kunugi; Freesia l Huang; Atsuko Hayata-Takano; Hitoshi Hashimoto; Kota Tamada; Toru Takumi; Takaoki Kasahara; Tadafumi Kato; Isabella a Graef; Gerald r Crabtree; Nozomi Asaoka; Hikari Hatakama; Shuji Kaneko; Takao Kohno; Mitsuharu Hattori; Yoshio Hoshiba; Ryuhei Miyake; Kisho Obi-Nagata; Akiko Hayashi-Takagi; Léa j Becker; Ipek Yalcin; Yoko Hagino; Hiroko Kotajima-Murakami; Yuki Moriya; Kazutaka Ikeda; Hyopil Kim; Bong-Kiun Kaang; Hikari Otabi; Yuta Yoshida; Atsushi Toyoda; Noboru h Komiyama; Seth gn Grant; Michiru Ida-Eto; Masaaki Narita; Ken-Ichi Matsumoto; Emiko Okuda-Ashitaka; Iori Ohmori; Tadayuki Shimada; Kanato Yamagata; Hiroshi Ageta; Kunihiro Tsuchida; Kaoru Inokuchi; Takayuki Sassa; Akio Kihara; Motoaki Fukasawa; Nobuteru Usuda; Tayo Katano; Teruyuki Tanaka; Yoshihiro Yoshihara; Michihiro Igarashi; Takashi Hayashi; Kaori Ishikawa; Satoshi Yamamoto; Naoya Nishimura; Kazuto Nakada; Shinji Hirotsune; Kiyoshi Egawa; Kazuma Higashisaka; Yasuo Tsutsumi; Shoko Nishihara; Noriyuki Sugo; Takeshi Yagi; Naoto Ueno; Tomomi Yamamoto; Yoshihiro Kubo; Rie Ohashi; Nobuyuki Shiina; Kimiko Shimizu; Sayaka Higo-Yamamoto; Katsutaka Oishi; Hisashi Mori; Tamio Furuse; Masaru Tamura; Hisashi Shirakawa; Daiki x Sato; Yukiko u Inoue; Takayoshi Inoue; Yuriko Komine; Tetsuo Yamamori; Kenji Sakimura; Tsuyoshi Miyakawa

doi:10.7554/eLife.89376.3

Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, Mikio Hoshino, Akito Nakao, Yasuo Mori, Shigeo Okabe, Masayuki Matsushita, Anja Urbach, Yuta Katayama, Akinobu Matsumoto, Keiichi i Nakayama, Shota KatoriTakuya Sato, Takuji Iwasato, Haruko Nakamura, Yoshio Goshima, Matthieu Raveau, Tetsuya Tatsukawa, Kazuhiro Yamakawa, Noriko Takahashi, Haruo Kasai, Johji Inazawa, Ikuo Nobuhisa, Tetsushi Kagawa, Tetsuya Taga, Mohamed Darwish, Hirofumi Nishizono, Keizo Takao, Kiran Sapkota, Kazutoshi Nakazawa, Tsuyoshi Takagi, Haruki Fujisawa, Yoshihisa Sugimura, Kyosuke Yamanishi, Lakshmi Rajagopal, Nanette deneen Hannah, Herbert y Meltzer, Tohru Yamamoto, Shuji Wakatsuki, Toshiyuki Araki, Katsuhiko Tabuchi, Tadahiro Numakawa, Hiroshi Kunugi, Freesia l Huang, Atsuko Hayata-Takano, Hitoshi Hashimoto, Kota Tamada, Toru Takumi, Takaoki Kasahara, Tadafumi Kato, Isabella a Graef, Gerald r Crabtree, Nozomi Asaoka, Hikari Hatakama, Shuji Kaneko, Takao Kohno, Mitsuharu Hattori, Yoshio Hoshiba, Ryuhei Miyake, Kisho Obi-Nagata, Akiko Hayashi-Takagi, Léa j Becker, Ipek Yalcin, Yoko Hagino, Hiroko Kotajima-Murakami, Yuki Moriya, Kazutaka Ikeda, Hyopil Kim, Bong-Kiun Kaang, Hikari Otabi, Yuta Yoshida, Atsushi Toyoda, Noboru h Komiyama, Seth gn Grant, Michiru Ida-Eto, Masaaki Narita, Ken-Ichi Matsumoto, Emiko Okuda-Ashitaka, Iori Ohmori, Tadayuki Shimada, Kanato Yamagata, Hiroshi Ageta, Kunihiro Tsuchida, Kaoru Inokuchi, Takayuki Sassa, Akio Kihara, Motoaki Fukasawa, Nobuteru Usuda, Tayo Katano, Teruyuki Tanaka, Yoshihiro Yoshihara, Michihiro Igarashi, Takashi Hayashi, Kaori Ishikawa, Satoshi Yamamoto, Naoya Nishimura, Kazuto Nakada, Shinji Hirotsune, Kiyoshi Egawa, Kazuma Higashisaka, Yasuo Tsutsumi, Shoko Nishihara, Noriyuki Sugo, Takeshi Yagi, Naoto Ueno, Tomomi Yamamoto, Yoshihiro Kubo, Rie Ohashi, Nobuyuki Shiina, Kimiko Shimizu, Sayaka Higo-Yamamoto, Katsutaka Oishi, Hisashi Mori, Tamio Furuse, Masaru Tamura, Hisashi Shirakawa, Daiki x Sato, Yukiko u Inoue, Takayoshi Inoue, Yuriko Komine, Tetsuo Yamamori, Kenji Sakimura, Tsuyoshi Miyakawa

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	eLIFE
Volume	12
DOIs	https://doi.org/10.7554/eLife.89376.3
Publication status	Published - 26 Mar 2024

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10.7554/eLife.89376.3

elife-89376-v1Final published version, 0.98 MBLicence: Creative Commons: CC0 - "No Rights Reserved"

https://elifesciences.org/articles/89376

Cite this

Hagihara, H., Shoji, H., Hattori, S., Sala, G., Takamiya, Y., Tanaka, M., Ihara, M., Shibutani, M., Hatada, I., Hori, K., Hoshino, M., Nakao, A., Mori, Y., Okabe, S., Matsushita, M., Urbach, A., Katayama, Y., Matsumoto, A., Nakayama, K. I., ... Miyakawa, T. (2024). Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment. eLIFE, 12. https://doi.org/10.7554/eLife.89376.3

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title = "Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment",

author = "Hideo Hagihara and Hirotaka Shoji and Satoko Hattori and Giovanni Sala and Yoshihiro Takamiya and Mika Tanaka and Masafumi Ihara and Mihiro Shibutani and Izuho Hatada and Kei Hori and Mikio Hoshino and Akito Nakao and Yasuo Mori and Shigeo Okabe and Masayuki Matsushita and Anja Urbach and Yuta Katayama and Akinobu Matsumoto and Nakayama, \{Keiichi i\} and Shota Katori and Takuya Sato and Takuji Iwasato and Haruko Nakamura and Yoshio Goshima and Matthieu Raveau and Tetsuya Tatsukawa and Kazuhiro Yamakawa and Noriko Takahashi and Haruo Kasai and Johji Inazawa and Ikuo Nobuhisa and Tetsushi Kagawa and Tetsuya Taga and Mohamed Darwish and Hirofumi Nishizono and Keizo Takao and Kiran Sapkota and Kazutoshi Nakazawa and Tsuyoshi Takagi and Haruki Fujisawa and Yoshihisa Sugimura and Kyosuke Yamanishi and Lakshmi Rajagopal and Hannah, \{Nanette deneen\} and Meltzer, \{Herbert y\} and Tohru Yamamoto and Shuji Wakatsuki and Toshiyuki Araki and Katsuhiko Tabuchi and Tadahiro Numakawa and Hiroshi Kunugi and Huang, \{Freesia l\} and Atsuko Hayata-Takano and Hitoshi Hashimoto and Kota Tamada and Toru Takumi and Takaoki Kasahara and Tadafumi Kato and Graef, \{Isabella a\} and Crabtree, \{Gerald r\} and Nozomi Asaoka and Hikari Hatakama and Shuji Kaneko and Takao Kohno and Mitsuharu Hattori and Yoshio Hoshiba and Ryuhei Miyake and Kisho Obi-Nagata and Akiko Hayashi-Takagi and Becker, \{L{\'e}a j\} and Ipek Yalcin and Yoko Hagino and Hiroko Kotajima-Murakami and Yuki Moriya and Kazutaka Ikeda and Hyopil Kim and Bong-Kiun Kaang and Hikari Otabi and Yuta Yoshida and Atsushi Toyoda and Komiyama, \{Noboru h\} and Grant, \{Seth gn\} and Michiru Ida-Eto and Masaaki Narita and Ken-Ichi Matsumoto and Emiko Okuda-Ashitaka and Iori Ohmori and Tadayuki Shimada and Kanato Yamagata and Hiroshi Ageta and Kunihiro Tsuchida and Kaoru Inokuchi and Takayuki Sassa and Akio Kihara and Motoaki Fukasawa and Nobuteru Usuda and Tayo Katano and Teruyuki Tanaka and Yoshihiro Yoshihara and Michihiro Igarashi and Takashi Hayashi and Kaori Ishikawa and Satoshi Yamamoto and Naoya Nishimura and Kazuto Nakada and Shinji Hirotsune and Kiyoshi Egawa and Kazuma Higashisaka and Yasuo Tsutsumi and Shoko Nishihara and Noriyuki Sugo and Takeshi Yagi and Naoto Ueno and Tomomi Yamamoto and Yoshihiro Kubo and Rie Ohashi and Nobuyuki Shiina and Kimiko Shimizu and Sayaka Higo-Yamamoto and Katsutaka Oishi and Hisashi Mori and Tamio Furuse and Masaru Tamura and Hisashi Shirakawa and Sato, \{Daiki x\} and Inoue, \{Yukiko u\} and Takayoshi Inoue and Yuriko Komine and Tetsuo Yamamori and Kenji Sakimura and Tsuyoshi Miyakawa",

year = "2024",

month = mar,

day = "26",

doi = "10.7554/eLife.89376.3",

language = "English",

volume = "12",

journal = "eLIFE",

issn = "2050-084X",

publisher = "ELIFE SCIENCES PUBLICATIONS LTD",

}

Hagihara, H, Shoji, H, Hattori, S, Sala, G, Takamiya, Y, Tanaka, M, Ihara, M, Shibutani, M, Hatada, I, Hori, K, Hoshino, M, Nakao, A, Mori, Y, Okabe, S, Matsushita, M, Urbach, A, Katayama, Y, Matsumoto, A, Nakayama, KI, Katori, S, Sato, T, Iwasato, T, Nakamura, H, Goshima, Y, Raveau, M, Tatsukawa, T, Yamakawa, K, Takahashi, N, Kasai, H, Inazawa, J, Nobuhisa, I, Kagawa, T, Taga, T, Darwish, M, Nishizono, H, Takao, K, Sapkota, K, Nakazawa, K, Takagi, T, Fujisawa, H, Sugimura, Y, Yamanishi, K, Rajagopal, L, Hannah, ND, Meltzer, HY, Yamamoto, T, Wakatsuki, S, Araki, T, Tabuchi, K, Numakawa, T, Kunugi, H, Huang, FL, Hayata-Takano, A, Hashimoto, H, Tamada, K, Takumi, T, Kasahara, T, Kato, T, Graef, IA, Crabtree, GR, Asaoka, N, Hatakama, H, Kaneko, S, Kohno, T, Hattori, M, Hoshiba, Y, Miyake, R, Obi-Nagata, K, Hayashi-Takagi, A, Becker, LJ, Yalcin, I, Hagino, Y, Kotajima-Murakami, H, Moriya, Y, Ikeda, K, Kim, H, Kaang, B-K, Otabi, H, Yoshida, Y, Toyoda, A, Komiyama, NH , Grant, SG, Ida-Eto, M, Narita, M, Matsumoto, K-I, Okuda-Ashitaka, E, Ohmori, I, Shimada, T, Yamagata, K, Ageta, H, Tsuchida, K, Inokuchi, K, Sassa, T, Kihara, A, Fukasawa, M, Usuda, N, Katano, T, Tanaka, T, Yoshihara, Y, Igarashi, M, Hayashi, T, Ishikawa, K, Yamamoto, S, Nishimura, N, Nakada, K, Hirotsune, S, Egawa, K, Higashisaka, K, Tsutsumi, Y, Nishihara, S, Sugo, N, Yagi, T, Ueno, N, Yamamoto, T, Kubo, Y, Ohashi, R, Shiina, N, Shimizu, K, Higo-Yamamoto, S, Oishi, K, Mori, H, Furuse, T, Tamura, M, Shirakawa, H, Sato, DX, Inoue, YU, Inoue, T, Komine, Y, Yamamori, T, Sakimura, K & Miyakawa, T 2024, 'Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment', eLIFE, vol. 12. https://doi.org/10.7554/eLife.89376.3

TY - JOUR

T1 - Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

AU - Hagihara, Hideo

AU - Shoji, Hirotaka

AU - Hattori, Satoko

AU - Sala, Giovanni

AU - Takamiya, Yoshihiro

AU - Tanaka, Mika

AU - Ihara, Masafumi

AU - Shibutani, Mihiro

AU - Hatada, Izuho

AU - Hori, Kei

AU - Hoshino, Mikio

AU - Nakao, Akito

AU - Mori, Yasuo

AU - Okabe, Shigeo

AU - Matsushita, Masayuki

AU - Urbach, Anja

AU - Katayama, Yuta

AU - Matsumoto, Akinobu

AU - Nakayama, Keiichi i

AU - Katori, Shota

AU - Sato, Takuya

AU - Iwasato, Takuji

AU - Nakamura, Haruko

AU - Goshima, Yoshio

AU - Raveau, Matthieu

AU - Tatsukawa, Tetsuya

AU - Yamakawa, Kazuhiro

AU - Takahashi, Noriko

AU - Kasai, Haruo

AU - Inazawa, Johji

AU - Nobuhisa, Ikuo

AU - Kagawa, Tetsushi

AU - Taga, Tetsuya

AU - Darwish, Mohamed

AU - Nishizono, Hirofumi

AU - Takao, Keizo

AU - Sapkota, Kiran

AU - Nakazawa, Kazutoshi

AU - Takagi, Tsuyoshi

AU - Fujisawa, Haruki

AU - Sugimura, Yoshihisa

AU - Yamanishi, Kyosuke

AU - Rajagopal, Lakshmi

AU - Hannah, Nanette deneen

AU - Meltzer, Herbert y

AU - Yamamoto, Tohru

AU - Wakatsuki, Shuji

AU - Araki, Toshiyuki

AU - Tabuchi, Katsuhiko

AU - Numakawa, Tadahiro

AU - Kunugi, Hiroshi

AU - Huang, Freesia l

AU - Hayata-Takano, Atsuko

AU - Hashimoto, Hitoshi

AU - Tamada, Kota

AU - Takumi, Toru

AU - Kasahara, Takaoki

AU - Kato, Tadafumi

AU - Graef, Isabella a

AU - Crabtree, Gerald r

AU - Asaoka, Nozomi

AU - Hatakama, Hikari

AU - Kaneko, Shuji

AU - Kohno, Takao

AU - Hattori, Mitsuharu

AU - Hoshiba, Yoshio

AU - Miyake, Ryuhei

AU - Obi-Nagata, Kisho

AU - Hayashi-Takagi, Akiko

AU - Becker, Léa j

AU - Yalcin, Ipek

AU - Hagino, Yoko

AU - Kotajima-Murakami, Hiroko

AU - Moriya, Yuki

AU - Ikeda, Kazutaka

AU - Kim, Hyopil

AU - Kaang, Bong-Kiun

AU - Otabi, Hikari

AU - Yoshida, Yuta

AU - Toyoda, Atsushi

AU - Komiyama, Noboru h

AU - Grant, Seth gn

AU - Ida-Eto, Michiru

AU - Narita, Masaaki

AU - Matsumoto, Ken-Ichi

AU - Okuda-Ashitaka, Emiko

AU - Ohmori, Iori

AU - Shimada, Tadayuki

AU - Yamagata, Kanato

AU - Ageta, Hiroshi

AU - Tsuchida, Kunihiro

AU - Inokuchi, Kaoru

AU - Sassa, Takayuki

AU - Kihara, Akio

AU - Fukasawa, Motoaki

AU - Usuda, Nobuteru

AU - Katano, Tayo

AU - Tanaka, Teruyuki

AU - Yoshihara, Yoshihiro

AU - Igarashi, Michihiro

AU - Hayashi, Takashi

AU - Ishikawa, Kaori

AU - Yamamoto, Satoshi

AU - Nishimura, Naoya

AU - Nakada, Kazuto

AU - Hirotsune, Shinji

AU - Egawa, Kiyoshi

AU - Higashisaka, Kazuma

AU - Tsutsumi, Yasuo

AU - Nishihara, Shoko

AU - Sugo, Noriyuki

AU - Yagi, Takeshi

AU - Ueno, Naoto

AU - Yamamoto, Tomomi

AU - Kubo, Yoshihiro

AU - Ohashi, Rie

AU - Shiina, Nobuyuki

AU - Shimizu, Kimiko

AU - Higo-Yamamoto, Sayaka

AU - Oishi, Katsutaka

AU - Mori, Hisashi

AU - Furuse, Tamio

AU - Tamura, Masaru

AU - Shirakawa, Hisashi

AU - Sato, Daiki x

AU - Inoue, Yukiko u

AU - Inoue, Takayoshi

AU - Komine, Yuriko

AU - Yamamori, Tetsuo

AU - Sakimura, Kenji

AU - Miyakawa, Tsuyoshi

PY - 2024/3/26

Y1 - 2024/3/26

U2 - 10.7554/eLife.89376.3

DO - 10.7554/eLife.89376.3

M3 - Article

SN - 2050-084X

VL - 12

JO - eLIFE

JF - eLIFE

ER -