Late-phase, protein synthesis-dependent long-term potentiation in hippocampal CA1 pyramidal neurones with destabilized microtubule networks

C A Vickers, D J A Wyllie

Research output: Contribution to journalArticlepeer-review

Abstract

Protein synthesis-dependent late-long term potentiation (L-LTP) is an enduring form of synaptic plasticity that has been shown to rely on, at least partly, protein synthesis at synaptic and/or dendritic sites. Evidence suggests that somatic transcription of new mRNAs may provide a significant contribution to the availability of mRNAs at synaptic sites where they are made available for dendritic translation. Transport of mRNAs from somatic to dendritic sites might be expected to involve movement along a microtubule network. In this study we examined whether it was possible to maintain L-LTP in hippocampal slices with destabilized microtubule networks.
Original languageEnglish
Pages (from-to)1071-7
Number of pages7
JournalBritish Journal of Pharmacology
Volume151
Issue number7
DOIs
Publication statusPublished - 2007

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