Latest advances in multimodality imaging of aortic stenosis

Evangelos Tzolos, Jacek Kwiecinski, Daniel Berman, Piotr Slomka, David E Newby, Marc R Dweck*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Aortic stenosis is a common condition associated with major morbidity, mortality and healthcare costs. Despite this, we currently lack any effective medical therapies that can treat or prevent disease development or progression. Modern advances in echocardiography and computed tomography (CT) have helped improve the assessment of aortic stenosis severity and monitoring of disease progression, whilst cardiac magnetic resonance imaging informs on myocardial health and the development of fibrosis. In a series of recent studies, 18F- sodium fluoride positron emission tomography and computed tomography has been shown to assess valvular disease activity and progression, providing mechanistic insights that can inform potential novel therapeutic approaches. This review will examine the latest advances in the imaging of aortic stenosis and bioprosthetic valve degeneration and explore how these techniques can assist patient management and potentially accelerate novel therapeutic developments.
Original languageEnglish
JournalJournal of Nuclear Medicine
DOIs
Publication statusPublished - 9 Dec 2021

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