Layered double hydroxides-silver-chlorin e6 nanocomposite for photo-chemo combination therapy to efficiently combat both Gram-positive and Gram-negative bacteria

Li Yan; Juan Li; Ashna Gopal; Sam Roberts; Jiafu Lin; Tingting Liu; Tasnim Munshi; Xiujuan Zhang; Michael Chen

doi:10.1016/j.mtcomm.2021.103101

Layered double hydroxides-silver-chlorin e6 nanocomposite for photo-chemo combination therapy to efficiently combat both Gram-positive and Gram-negative bacteria

Li Yan, Juan Li, Ashna Gopal, Sam Roberts, Jiafu Lin, Tingting Liu, Tasnim Munshi, Xiujuan Zhang, Michael Chen

School of Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Antibiotics play an important role in the treatment of infectious diseases. However, the growing threat of drug-resistant bacteria has limited the availability and effectiveness of antibiotics. Here, we introduced an antibiotic nanocomposite using biocompatible and biodegradable layered double hydroxides as a matrix, followed by covalent conjugation of a photosensitizer, chlorin e6 (Ce6), and in-situ doping of silver nanoparticles for synergistic photo-chemo combination therapy to effectively kill both Gram-positive and Gram-negative bacteria. This layered double hydroxides-silver-chlorin e6 nanocomposite could be potentially utilized for treating various bacterial infections and overcoming bacterial resistance.

Original language	English
Article number	103101
Journal	Materials Today Communications
Volume	30
Early online date	21 Dec 2021
DOIs	https://doi.org/10.1016/j.mtcomm.2021.103101
Publication status	Published - 1 Mar 2022

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10.1016/j.mtcomm.2021.103101

Revision_Clean_VersionAccepted author manuscript, 3.81 MB

Biocompatible and biodegradable monodisperse zeolitic imidazolate framework-8 (ZIF-8) nanoparticles for efficient and safe nanomedicine (Royal Society Research Grant)
Chen, M. (Principal Investigator)
Other (Learned Society)
1/06/16 → 30/09/17
Project: Research

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title = "Layered double hydroxides-silver-chlorin e6 nanocomposite for photo-chemo combination therapy to efficiently combat both Gram-positive and Gram-negative bacteria",

abstract = "Antibiotics play an important role in the treatment of infectious diseases. However, the growing threat of drug-resistant bacteria has limited the availability and effectiveness of antibiotics. Here, we introduced an antibiotic nanocomposite using biocompatible and biodegradable layered double hydroxides as a matrix, followed by covalent conjugation of a photosensitizer, chlorin e6 (Ce6), and in-situ doping of silver nanoparticles for synergistic photo-chemo combination therapy to effectively kill both Gram-positive and Gram-negative bacteria. This layered double hydroxides-silver-chlorin e6 nanocomposite could be potentially utilized for treating various bacterial infections and overcoming bacterial resistance.",

author = "Li Yan and Juan Li and Ashna Gopal and Sam Roberts and Jiafu Lin and Tingting Liu and Tasnim Munshi and Xiujuan Zhang and Michael Chen",

note = "Funding Information: The authors acknowledge the support provided from National Natural Science Foundation of China (No. 81803480 , 2167315 , 11811530640 ), the Chengdu University (No. 2081916010 ), School of Engineering of The University of Edinburgh , and the Royal Society Research Grant Scheme RG150564 . L. Yan and J. Li contributed equally to this work. Publisher Copyright: {\textcopyright} 2022 Elsevier Ltd",

year = "2022",

month = mar,

day = "1",

doi = "10.1016/j.mtcomm.2021.103101",

language = "English",

volume = "30",

journal = "Materials Today Communications",

issn = "2352-4928",

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TY - JOUR

T1 - Layered double hydroxides-silver-chlorin e6 nanocomposite for photo-chemo combination therapy to efficiently combat both Gram-positive and Gram-negative bacteria

AU - Yan, Li

AU - Li, Juan

AU - Gopal, Ashna

AU - Roberts, Sam

AU - Lin, Jiafu

AU - Liu, Tingting

AU - Munshi, Tasnim

AU - Zhang, Xiujuan

AU - Chen, Michael

N1 - Funding Information: The authors acknowledge the support provided from National Natural Science Foundation of China (No. 81803480 , 2167315 , 11811530640 ), the Chengdu University (No. 2081916010 ), School of Engineering of The University of Edinburgh , and the Royal Society Research Grant Scheme RG150564 . L. Yan and J. Li contributed equally to this work. Publisher Copyright: © 2022 Elsevier Ltd

PY - 2022/3/1

Y1 - 2022/3/1

N2 - Antibiotics play an important role in the treatment of infectious diseases. However, the growing threat of drug-resistant bacteria has limited the availability and effectiveness of antibiotics. Here, we introduced an antibiotic nanocomposite using biocompatible and biodegradable layered double hydroxides as a matrix, followed by covalent conjugation of a photosensitizer, chlorin e6 (Ce6), and in-situ doping of silver nanoparticles for synergistic photo-chemo combination therapy to effectively kill both Gram-positive and Gram-negative bacteria. This layered double hydroxides-silver-chlorin e6 nanocomposite could be potentially utilized for treating various bacterial infections and overcoming bacterial resistance.

AB - Antibiotics play an important role in the treatment of infectious diseases. However, the growing threat of drug-resistant bacteria has limited the availability and effectiveness of antibiotics. Here, we introduced an antibiotic nanocomposite using biocompatible and biodegradable layered double hydroxides as a matrix, followed by covalent conjugation of a photosensitizer, chlorin e6 (Ce6), and in-situ doping of silver nanoparticles for synergistic photo-chemo combination therapy to effectively kill both Gram-positive and Gram-negative bacteria. This layered double hydroxides-silver-chlorin e6 nanocomposite could be potentially utilized for treating various bacterial infections and overcoming bacterial resistance.

U2 - 10.1016/j.mtcomm.2021.103101

DO - 10.1016/j.mtcomm.2021.103101

M3 - Article

SN - 2352-4928

VL - 30

JO - Materials Today Communications

JF - Materials Today Communications

M1 - 103101

ER -

Layered double hydroxides-silver-chlorin e6 nanocomposite for photo-chemo combination therapy to efficiently combat both Gram-positive and Gram-negative bacteria

Abstract

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Projects

Biocompatible and biodegradable monodisperse zeolitic imidazolate framework-8 (ZIF-8) nanoparticles for efficient and safe nanomedicine (Royal Society Research Grant)

Cite this