Layered double hydroxides-silver-chlorin e6 nanocomposite for photo-chemo combination therapy to efficiently combat both Gram-positive and Gram-negative bacteria

Li Yan, Juan Li, Ashna Gopal, Sam Roberts, Jiafu Lin, Tingting Liu, Tasnim Munshi, Xiujuan Zhang, Michael Chen

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Antibiotics play an important role in the treatment of infectious diseases. However, the growing threat of drug-resistant bacteria has limited the availability and effectiveness of antibiotics. Here, we introduced an antibiotic nanocomposite using biocompatible and biodegradable layered double hydroxides as a matrix, followed by covalent conjugation of a photosensitizer, chlorin e6 (Ce6), and in-situ doping of silver nanoparticles for synergistic photo-chemo combination therapy to effectively kill both Gram-positive and Gram-negative bacteria. This layered double hydroxides-silver-chlorin e6 nanocomposite could be potentially utilized for treating various bacterial infections and overcoming bacterial resistance.
Original languageEnglish
Article number103101
JournalMaterials Today Communications
Volume30
Early online date21 Dec 2021
DOIs
Publication statusPublished - 1 Mar 2022

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