Left atrial adaptation in ischemic heart disease: insights from a cardiovascular magnetic resonance study

Anna Giulia Pavon, Pier Giorgio Masci, Lorenzo Pucci, Antonio Landi, Amit Bermano, Amir Vaxman, Craig Gotsman, Tobias Rutz, Pierre Monney, Rita Godihno, David Saraiva Rodrigues, Olivier Muller, Marco Valgimigli, Juerg Schwitter

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Left atrium (LA) plays a key role in the overall cardiac performance. However, it remains unclear how LA adapts, in terms of function and volumes, to left ventricular dysfunction in the acute and post-acute phases of myocardial infarction. LA volumes and function were evaluated in patients in the acute phase of ST-segment elevation myocardial infarction (acute-STEMI group) and in the post-acute phase after STEMI (post-acute STEMI group). Ten age and sex-matched healthy controls served as control group. In all subjects LA was assessed by a compressed-sensing cine pulse sequence and by a 3D non-model-based reconstruction. LV infarct size and microvascular obstruction were determined on late-gadolinium-enhancement data and LV myocardial oedema and myocardial haemorrhage were measured on T2-mapping data. Indexed LA maximum and minimum volumes did not differ between the acute (n = 50) and post-acute (n = 47) STEMI groups. LA active emptying fraction (LAAEF) was higher in the acute-STEMI as compared with the post-acute STEMI groups (0.63 ± 0.23 vs 0.37 ± 0.24, p 
Original languageEnglish
Pages (from-to)1533-1543
Number of pages11
JournalThe International Journal of Cardiovascular Imaging
Issue number7
Early online date17 Feb 2022
Publication statusPublished - 1 Jul 2022

Keywords / Materials (for Non-textual outputs)

  • ST-segment elevation myocardial infarction
  • Cardiovascular magnetic resonance
  • Left atrium
  • Left atrium function


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