Abstract
Recollection and familiarity represent two processes involved in episodic memory retrieval. We investigated how scopolamine (an antagonist of acetylcholine muscarinic receptors) influenced brain activity during memory retrieval, using a paradigm that separated recollection and familiarity. Eighteen healthy volunteers were recruited in a randomized, placebo-controlled, double-blind design using event-related fMRI. Participants were required to perform a verbal recognition memory task within the scanner, either under placebo or scopolamine conditions. Depending on the subcondition, participants were required to make a simple recognition decision (old/new items) or base their decision on more specific information related to prior experience (target/non-target/new items). We show a drug modulation in left prefrontal and perirhinal cortex during recollection. Such an effect was specifically driven by novelty and showed an inverse correlation with accuracy performance. Additionally, we show a direct correlation between drug-related signal change in left prefrontal and perirhinal cortices. We discuss the findings in terms of acetylcholine mediation of the familiarity/novelty signal through perirhinal cortex and the control of the relative signal strength through prefrontal cortex. (c) 2006 Elsevier Inc. All rights reserved.
Original language | English |
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Pages (from-to) | 286-295 |
Number of pages | 10 |
Journal | NeuroImage |
Volume | 33 |
Issue number | 1 |
DOIs | |
Publication status | Published - 15 Oct 2006 |
Keywords / Materials (for Non-textual outputs)
- fMRI
- scopolamine
- episodic memory
- recollection
- familiarity
- ANTERIOR COMMUNICATING ARTERY
- EPISODIC MEMORY RETRIEVAL
- RECOGNITION MEMORY
- MONITORING HYPOTHESIS
- FAMILIARITY
- AMNESIA
- CONFABULATION
- HIPPOCAMPAL
- ANEURYSM
- LESIONS