Left-right asymmetry in gut development: what happens next?

Sally F Burn, Robert E Hill

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

The gastrointestinal tract is an asymmetrically patterned organ system. The signals which initiate left-right asymmetry in the developing embryo have been extensively studied, but the downstream steps required to confer asymmetric morphogenesis on the gut organ primordia are less well understood. In this paper we outline key findings on the tissue mechanics underlying gut asymmetry, across a range of species, and use these to synthesise a conserved model for asymmetric gut morphogenesis. We also discuss the importance of correct establishment of left-right asymmetry for gut development and the consequences of perturbations in this process.
Original languageEnglish
Pages (from-to)1026-37
Number of pages12
JournalBioEssays
Volume31
Issue number10
DOIs
Publication statusPublished - Oct 2009

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