Leprosy epidemics during history increased protective allele frequency of PARK2/PACRG genes in the population of the Mljet Island, Croatia

A Bakija-Konsuo; R Mulić; V Boraska; M Pehlic; J E Huffman; C Hayward; M Marlais; T Zemunik; I Rudan

doi:10.1016/j.ejmg.2011.06.010

Leprosy epidemics during history increased protective allele frequency of PARK2/PACRG genes in the population of the Mljet Island, Croatia

A Bakija-Konsuo, R Mulić, V Boraska, M Pehlic, J E Huffman, C Hayward, M Marlais, T Zemunik, I Rudan

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Two regulatory polymorphisms (rs1040079 and rs9356058) shared by PARK2 and PACRG genes were identified as major risk variants for leprosy susceptibility. The aim of this study was to investigate if allele frequencies of these polymorphisms in the isolated population of the island of Mljet, which served as a quarantine for leprosy patients during past centuries, were different to allele frequencies in two control populations with no history of leprosy.

Original language	English
Pages (from-to)	e548-52
Journal	European journal of medical genetics
Volume	54
Issue number	6
DOIs	https://doi.org/10.1016/j.ejmg.2011.06.010
Publication status	Published - 2011

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10.1016/j.ejmg.2011.06.010

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title = "Leprosy epidemics during history increased protective allele frequency of PARK2/PACRG genes in the population of the Mljet Island, Croatia",

abstract = "Two regulatory polymorphisms (rs1040079 and rs9356058) shared by PARK2 and PACRG genes were identified as major risk variants for leprosy susceptibility. The aim of this study was to investigate if allele frequencies of these polymorphisms in the isolated population of the island of Mljet, which served as a quarantine for leprosy patients during past centuries, were different to allele frequencies in two control populations with no history of leprosy.",

author = "A Bakija-Konsuo and R Muli{\'c} and V Boraska and M Pehlic and Huffman, {J E} and C Hayward and M Marlais and T Zemunik and I Rudan",

year = "2011",

doi = "10.1016/j.ejmg.2011.06.010",

language = "English",

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T1 - Leprosy epidemics during history increased protective allele frequency of PARK2/PACRG genes in the population of the Mljet Island, Croatia

AU - Bakija-Konsuo, A

AU - Mulić, R

AU - Boraska, V

AU - Pehlic, M

AU - Huffman, J E

AU - Hayward, C

AU - Marlais, M

AU - Zemunik, T

AU - Rudan, I

PY - 2011

Y1 - 2011

N2 - Two regulatory polymorphisms (rs1040079 and rs9356058) shared by PARK2 and PACRG genes were identified as major risk variants for leprosy susceptibility. The aim of this study was to investigate if allele frequencies of these polymorphisms in the isolated population of the island of Mljet, which served as a quarantine for leprosy patients during past centuries, were different to allele frequencies in two control populations with no history of leprosy.

AB - Two regulatory polymorphisms (rs1040079 and rs9356058) shared by PARK2 and PACRG genes were identified as major risk variants for leprosy susceptibility. The aim of this study was to investigate if allele frequencies of these polymorphisms in the isolated population of the island of Mljet, which served as a quarantine for leprosy patients during past centuries, were different to allele frequencies in two control populations with no history of leprosy.

U2 - 10.1016/j.ejmg.2011.06.010

DO - 10.1016/j.ejmg.2011.06.010

M3 - Article

C2 - 21816242

VL - 54

SP - e548-52

JO - European journal of medical genetics

JF - European journal of medical genetics

SN - 1769-7212

IS - 6

ER -

Leprosy epidemics during history increased protective allele frequency of PARK2/PACRG genes in the population of the Mljet Island, Croatia

Abstract

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